Clinicians managing colorectal cancer patients need to appreciate that more than 60% of
their patients are> 70 years of age, and that these proportions may increase further in the …

For more than three decades, postoperative chemotherapy—initially fluoropyrimidines and
more recently combinations with oxaliplatin—has reduced the risk of tumor recurrence and …

Background The role of adjuvant chemotherapy in stage II colon cancer continues to be
debated. The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor …

METHODS This guideline is based on the previous colon cancer parameter published in
2017. 10 Compared with 2017, this guideline has 11 new, 10 updated, and 2 excluded …

PURPOSE To develop recommendations for adjuvant therapy for patients with resected
stage II colon cancer. METHODS ASCO convened an Expert Panel to conduct a systematic …

The NCCN Guidelines for Colon Cancer provide recommendations regarding diagnosis,
pathologic staging, surgical management, perioperative treatment, surveillance …

This portion of the NCCN Guidelines for Colon Cancer focuses on the use of systemic
therapy in metastatic disease. Considerations for treatment selection among 32 different …

Purpose The MOSAIC (Multicenter International Study of Oxaliplatin/Fluorouracil/Leucovorin
in the Adjuvant Treatment of Colon Cancer) study has demonstrated 3-year disease-free …

PURPOSE: In patients with stage III colon cancer (CC) whose tumors demonstrate
microsatellite instability (MSI), the efficacy of adjuvant fluoropyrimidine (FP) with or without …

Abstract The American Society of Colon and Rectal Surgeons is dedicated to ensuring high-
quality patient care by advancing the science, prevention, and management of disorders …