Strategies in translating the therapeutic potentials of host defense peptides

DSJ Ting, RW Beuerman, HS Dua… - Frontiers in …, 2020 - frontiersin.org
The golden era of antibiotics, heralded by the discovery of penicillin, has long been
challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides …

Unnatural amino acids: Promising implications for the development of new antimicrobial peptides

X Wang, X Yang, Q Wang, D Meng - Critical Reviews in …, 2023 - Taylor & Francis
The increasing incidence and rapid spread of bacterial resistance to conventional antibiotics
are a serious global threat to public health, highlighting the need to develop new …

Antimicrobial peptides: potential alternative to antibiotics and overcoming limitations for future therapeutic applications

V Somase, SA Desai, VP Patel, V Patil… - International Journal of …, 2024 - Springer
Among all health-related issues, the rising concerns about drug resistance led to the look for
alternative pharmaceutical drugs that are effective against both infectious and noninfectious …

Rational design of hybrid peptide with high antimicrobial property derived from Melittin and Lasioglossin

S Nabizadeh, L Rahbarnia, J Nowrozi… - Journal of …, 2024 - Taylor & Francis
Abstract Hybridization of Antimicrobial peptides (AMPs) with unique abilities is now
considered to improve AMPs' function as promising therapeutic candidates. In the current …

Functional and toxicological evaluation of MAA-41: A novel rationally designed antimicrobial peptide using hybridization and modification methods from LL-37 and …

M Masadeh, A Ayyad, R Haddad… - Current …, 2022 - benthamdirect.com
Background: Managing bacterial infections caused by multidrug-resistant (MDR) and
biofilmforming bacteria is a global health concern. Therefore, enormous efforts were directed …

[PDF][PDF] Current and emerging therapies for corneal infection: a clinical and laboratory study

DSJ Ting - 2022 - researchgate.net
Corneal infection or infectious keratitis (IK) is a major cause for corneal blindness worldwide.
Broad-spectrum antimicrobial therapy is currently the mainstay of treatment for IK, but the …