Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders
SB Nelson, V Valakh - Neuron, 2015 - cell.com
Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition …
mutations in many genes affecting the ratio between neuronal excitation and inhibition …
Developmental timing and critical windows for the treatment of psychiatric disorders
O Marín - Nature medicine, 2016 - nature.com
There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …
insults during sensitive periods in brain development have long-term consequences on …
Altered neuronal and circuit excitability in fragile X syndrome
Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a
phenotypically complex disorder with a range of neurological and psychiatric problems …
phenotypically complex disorder with a range of neurological and psychiatric problems …
Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability.
Previous studies have implicated mGlu5 in the pathogenesis of the disease, but a crucial …
Previous studies have implicated mGlu5 in the pathogenesis of the disease, but a crucial …
Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses
Mutations that cause intellectual disability (ID) and autism spectrum disorder (ASD) are
commonly found in genes that encode for synaptic proteins. However, it remains unclear …
commonly found in genes that encode for synaptic proteins. However, it remains unclear …
The perineuronal 'safety'net? Perineuronal net abnormalities in neurological disorders
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …
Fragile X syndrome: a review of associated medical problems
SA Kidd, A Lachiewicz, D Barbouth, RK Blitz… - …, 2014 - publications.aap.org
Fragile X syndrome (FXS) is the most common known genetic cause of inherited intellectual
disability and the most common known single-gene cause of autism spectrum disorder. It …
disability and the most common known single-gene cause of autism spectrum disorder. It …
Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome
Despite the pronounced neurological deficits associated with mental retardation and autism,
it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here …
it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here …
Sensitive and critical periods during neurotypical and aberrant neurodevelopment: a framework for neurodevelopmental disorders
RM Meredith - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
During sensitive and critical periods, the brain undergoes significant plasticity from the level
of individual synapses and neuronal networks up to the level of behaviour. Both sensitive …
of individual synapses and neuronal networks up to the level of behaviour. Both sensitive …
Circuit level defects in the develo** neocortex of Fragile X mice
Subtle alterations in how cortical network dynamics are modulated by different behavioral
states could disrupt normal brain function and underlie symptoms of neuropsychiatric …
states could disrupt normal brain function and underlie symptoms of neuropsychiatric …