An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder

BS Da Silva, EH Grevet, LCF Silva, JKN Ramos… - Discover Mental …, 2023 - Springer
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent psychiatric condition
characterized by developmentally inappropriate symptoms of inattention and/or …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

H Zhou, RL Kember, JD Deak, H Xu, S Toikumo… - Nature Medicine, 2023 - nature.com
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …

Examining the shared etiology of psychopathology with genome-wide association studies

TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample

M Moses, J Tiego, D Demontis, G Bragi Walters… - Molecular …, 2022 - nature.com
Endophenotypes are heritable and quantifiable traits indexing genetic liability for a disorder.
Here, we examined three potential endophenotypes, working memory function, response …

Annual Research Review: Perspectives on progress in ADHD science–from characterization to cause

EJS Sonuga‐Barke, SP Becker, S Bölte… - Journal of child …, 2023 - Wiley Online Library
The science of attention‐deficit/hyperactivity disorder (ADHD) is motivated by a translational
goal–the discovery and exploitation of knowledge about the nature of ADHD to the benefit of …

The course of attention-deficit/hyperactivity disorder through midlife

EH Grevet, CE Bandeira, ES Vitola… - European Archives of …, 2024 - Springer
The course of ADHD from childhood up to young adulthood has been characterized in
several studies. However, little is known about the course of symptoms into middle age and …

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses

TD Als, MI Kurki, J Grove, G Voloudakis, K Therrien… - Nature medicine, 2023 - nature.com
Depression is a common psychiatric disorder and a leading cause of disability worldwide.
Here we conducted a genome-wide association study meta-analysis of six datasets …

Rare copy number variants in males and females with childhood attention-deficit/hyperactivity disorder

B Jung, K Ahn, C Justice, L Norman, J Price… - Molecular …, 2023 - nature.com
While childhood attention-deficit/hyperactivity disorder (ADHD) is more prevalent in males
than females, genetic contributors to this effect have not been established. Here, we explore …

Comprehensive analysis of omics data identifies relevant gene networks for Attention-Deficit/Hyperactivity Disorder (ADHD)

J Cabana-Domínguez, M Soler Artigas… - Translational …, 2022 - nature.com
Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental
disorder that results from the interaction of both genetic and environmental risk factors …