Mitonuclear communication in homeostasis and stress
Mitochondria participate in crucial cellular processes such as energy harvesting and
intermediate metabolism. Although mitochondria possess their own genome—a vestige of …
intermediate metabolism. Although mitochondria possess their own genome—a vestige of …
[HTML][HTML] Thyroid hormone regulation of metabolism
R Mullur, YY Liu, GA Brent - Physiological reviews, 2014 - journals.physiology.org
Thyroid hormone (TH) is required for normal development as well as regulating metabolism
in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially …
in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially …
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets
The genetic, biologic, and clinical heterogeneity of sarcomas poses a challenge for the
identification of therapeutic targets, clinical research, and advancing patient care. Because …
identification of therapeutic targets, clinical research, and advancing patient care. Because …
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial
function and to adapt cellular metabolism to stress. Using a multiomics approach in …
function and to adapt cellular metabolism to stress. Using a multiomics approach in …
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
The biological effects of urolithins remain poorly characterized, despite wide-spread human
exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which …
exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which …
Paradigms of dynamic control of thyroid hormone signaling
Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …
[HTML][HTML] The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
NAD+ is an important cofactor regulating metabolic homeostasis and a rate-limiting
substrate for sirtuin deacylases. We show that NAD+ levels are reduced in aged mice and …
substrate for sirtuin deacylases. We show that NAD+ levels are reduced in aged mice and …
Sirtuins as regulators of metabolism and healthspan
Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1–
SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing …
SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing …
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary
restriction consistently extends lifespan and delays age-related diseases in evolutionarily …
restriction consistently extends lifespan and delays age-related diseases in evolutionarily …
NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation
Neuromuscular diseases are often caused by inherited mutations that lead to progressive
skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice …
skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice …