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[HTML][HTML] mTOR substrate phosphorylation in growth control
The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …
serine/threonine protein kinase that plays a central role in regulating cell growth and …
Functional roles of sphingolipids in immunity and their implication in disease
Sphingolipids, which are components of cellular membranes and organ tissues, can be
synthesized or degraded to modulate cellular responses according to environmental cues …
synthesized or degraded to modulate cellular responses according to environmental cues …
IL-10 constrains sphingolipid metabolism to limit inflammation
Abstract Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that can limit immune cell
activation and cytokine production in innate immune cell types. Loss of IL-10 signalling …
activation and cytokine production in innate immune cell types. Loss of IL-10 signalling …
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects
Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders
SM Stanford, N Bottini - Nature Reviews Drug Discovery, 2023 - nature.com
Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …
attractive therapeutic targets for various diseases. Although extensive effort has been …
Metabolic coordination of T cell quiescence and activation
Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …
Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos
CD4+ regulatory T (Treg) cells accumulate in the tumor microenvironment (TME) and
suppress the immune system. Whether and how metabolite availability in the TME …
suppress the immune system. Whether and how metabolite availability in the TME …
Sphingolipids and their metabolism in physiology and disease
Studies of bioactive lipids in general and sphingolipids in particular have intensified over the
past several years, revealing an unprecedented and unanticipated complexity of the …
past several years, revealing an unprecedented and unanticipated complexity of the …
The balance of Th17 versus Treg cells in autoimmunity
T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the
naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial …
naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial …
The multiple pathways to autoimmunity
Efforts to understand autoimmunity have been pursued relentlessly for several decades. It
has become apparent that the immune system evolved multiple mechanisms for controlling …
has become apparent that the immune system evolved multiple mechanisms for controlling …