Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Functional characterization of pseudouridine (Ψ) in mammalian mRNA has been hampered
by the lack of a quantitative method that maps Ψ in the whole transcriptome. We report …

Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …

Nanopore RNA sequencing shows promise as a method for discriminating and identifying
different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing …

RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …

Pseudouridine (Ψ) is an abundant post-transcriptional RNA modification in ncRNA and
mRNA. However, stoichiometric measurement of individual Ψ sites in human transcriptome …

RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

Pseudouridine is a modified nucleotide that is prevalent in human mRNAs and is
dynamically regulated. Here, we investigate when in their life cycle mRNAs become …