All organisms must sense and respond to their external environments, and this signal
transduction often involves second messengers such as cyclic nucleotides. One such …

Plasmodium spp. parasites that cause malaria disease remain a significant global-health
burden. With the spread of parasites resistant to artemisinin combination therapies in …

Erythrocytes carrying a variant hemoglobin allele (HbS), which causes sickle cell disease
and resists infection by the malaria parasite Plasmodium falciparum. The molecular basis of …

Abstract Calcium Dependent Protein Kinases are key effectors of calcium signaling in
malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum, but …

Chronobiology plays a crucial role in modulating many physiologic systems in which there is
nutritional synergism with meal timing. Given that intermittent fasting (IF) has grown as a …

Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in
malaria parasites is poorly understood. We have investigated the role of cAMP in asexual …

Melatonin, a hormone secreted by the pineal gland, works directly and indirectly as a free
radical scavenger. Its other physiological or pharmacological activities could be dependent …

The cell cycle is a critical component of cellular proliferation, differentiation, and response to
stress, yet its role in the regulation of intracellular symbioses is not well understood. To …

Apicomplexan parasites are obligate intracellular parasites that infect a variety of hosts,
causing significant diseases in livestock and humans. The invasive forms of the parasites …

Protein kinases (PKs) play crucial roles in the control of proliferation and differentiation in
eukaryotic cells. Research on protein phosphorylation has expanded tremendously in the …