Cell-type deconvolution from DNA methylation: a review of recent applications
Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …
the biology underlying disease development and progression. DNA methylation (DNAm) …
Improved survival analysis by learning shared genomic information from pan-cancer data
Motivation Recent advances in deep learning have offered solutions to many biomedical
tasks. However, there remains a challenge in applying deep learning to survival analysis …
tasks. However, there remains a challenge in applying deep learning to survival analysis …
TOAST: improving reference-free cell composition estimation by cross-cell type differential analysis
In the analysis of high-throughput data from complex samples, cell composition is an
important factor that needs to be accounted for. Except for a limited number of tissues with …
important factor that needs to be accounted for. Except for a limited number of tissues with …
Proteomic analysis of exosome-enriched fractions derived from cerebrospinal fluid of amyotrophic lateral sclerosis patients
N Hayashi, H Doi, Y Kurata, H Kagawa, Y Atobe… - Neuroscience …, 2020 - Elsevier
Exosomes contain many proteins associated with neurodegenerative diseases. To identify
new candidate biomarkers and proteins associated with amyotrophic lateral sclerosis (ALS) …
new candidate biomarkers and proteins associated with amyotrophic lateral sclerosis (ALS) …
Autoencoded DNA methylation data to predict breast cancer recurrence: Machine learning models and gene-weight significance
L Macías-García, M Martinez-Ballesteros… - Artificial Intelligence in …, 2020 - Elsevier
Breast cancer is the most frequent cancer in women and the second most frequent overall
after lung cancer. Although the 5-year survival rate of breast cancer is relatively high …
after lung cancer. Although the 5-year survival rate of breast cancer is relatively high …
The dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers
Background The evidence for epigenome-wide associations between smoking and DNA
methylation continues to grow through cross-sectional studies. However, few large-scale …
methylation continues to grow through cross-sectional studies. However, few large-scale …
Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway
Z Liu, M Zhao, X Jiang, Y Zhang, S Zhang, Y Xu… - Laboratory …, 2022 - nature.com
Abstract Analysis of the Gene Expression Profiling Interactive Analysis (GEPIA) database
revealed that Kelch-like 17 (KLHL17) is overexpressed in non-small cell lung cancer …
revealed that Kelch-like 17 (KLHL17) is overexpressed in non-small cell lung cancer …
RNA-seq as a tool for evaluating human embryo competence
AF Groff, N Resetkova, F DiDomenico… - Genome …, 2019 - genome.cshlp.org
The majority of embryos created through in vitro fertilization (IVF) do not implant. It seems
plausible that rates of implantation would improve if we had a better understanding of …
plausible that rates of implantation would improve if we had a better understanding of …
Immune infiltration-related genes regulate the progression of AML by invading the bone marrow microenvironment
S Yu, J Jiang - Frontiers in Immunology, 2024 - frontiersin.org
In this study, we try to find the pathogenic role of immune-related genes in the bone marrow
microenvironment of AML. Through WGCNA, seven modules were obtained, among which …
microenvironment of AML. Through WGCNA, seven modules were obtained, among which …
[HTML][HTML] DNA methylation in genes of longevity-regulating pathways: association with obesity and metabolic complications
Aging is the main risk factor for most chronic diseases. Epigenetic mechanisms, such as
DNA methylation (DNAm) plays a pivotal role in the regulation of physiological responses …
DNA methylation (DNAm) plays a pivotal role in the regulation of physiological responses …