Neuroinflammation and oxidative stress in the pathogenesis of autism spectrum disorder

N Usui, H Kobayashi, S Shimada - International journal of molecular …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by
impairments in social communication, repetitive behaviors, restricted interests, and …

Oxidative stress marker aberrations in children with autism spectrum disorder: a systematic review and meta-analysis of 87 studies (N = 9109)

L Chen, XJ Shi, H Liu, X Mao, LN Gui, H Wang… - Translational …, 2021 - nature.com
There is increasing awareness that oxidative stress may be implicated in the
pathophysiology of autism spectrum disorder (ASD). Here we aimed to investigate blood …

[HTML][HTML] High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways

HW Mendes, U Neelakantan, Y Liu, SE Fitzpatrick… - Cell reports, 2023 - cell.com
Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …

Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development

M Shen, CL Sirois, Y Guo, M Li, Q Dong… - Neuron, 2023 - cell.com
Fragile X messenger ribonucleoprotein 1 protein (FMRP) deficiency leads to fragile X
syndrome (FXS), an autism spectrum disorder. The role of FMRP in prenatal human brain …

The role of glutathione redox imbalance in autism spectrum disorder: A review

G Bjørklund, AA Tinkov, B Hosnedlová, R Kizek… - Free Radical Biology …, 2020 - Elsevier
The role of glutathione in autism spectrum disorder (ASD) is emerging as a major topic, due
to its role in the maintenance of the intracellular redox balance. Several studies have …

Mitochondria, metabolism, and redox mechanisms in psychiatric disorders

Y Kim, KC Vadodaria, Z Lenkei, T Kato… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia

I Khadimallah, R Jenni, JH Cabungcal, M Cleusix… - Molecular …, 2022 - nature.com
Early detection and intervention in schizophrenia requires mechanism-based biomarkers
that capture neural circuitry dysfunction, allowing better patient stratification, monitoring of …

Mitochondrial protein biogenesis in the synapse is supported by local translation

B Kuzniewska, D Cysewski, M Wasilewski… - EMBO …, 2020 - embopress.org
Synapses are the regions of the neuron that enable the transmission and propagation of
action potentials on the cost of high energy consumption and elevated demand for …

[HTML][HTML] Folic acid and autism: a systematic review of the current state of knowledge

B Hoxha, M Hoxha, E Domi, J Gervasoni, S Persichilli… - Cells, 2021 - mdpi.com
Folic acid has been identified to be integral in rapid tissue growth and cell division during
fetal development. Different studies indicate folic acid's importance in improving childhood …

[HTML][HTML] The pathophysiological role of CoA

A Czumaj, S Szrok-Jurga, A Hebanowska… - International Journal of …, 2020 - mdpi.com
The importance of coenzyme A (CoA) as a carrier of acyl residues in cell metabolism is well
understood. Coenzyme A participates in more than 100 different catabolic and anabolic …