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Bacterial Argonaute nucleases reveal different modes of DNA targeting in vitro and in vivo
L Lisitskaya, E Kropocheva, A Agapov… - Nucleic Acids …, 2023 - academic.oup.com
Prokaryotic Argonaute proteins (pAgos) are homologs of eukaryotic Argonautes (eAgos) and
are also thought to play a role in cell defense against invaders. However, pAgos are much …
are also thought to play a role in cell defense against invaders. However, pAgos are much …
In vivo PIWI slicing in mouse testes deviates from rules established in vitro
M Dowling, D Homolka, N Raad, P Gos, RR Pandey… - Rna, 2023 - rnajournal.cshlp.org
Argonautes are small RNA-binding proteins, with some having small RNA-guided
endonuclease (slicer) activity that cleaves target nucleic acids. One cardinal rule that is …
endonuclease (slicer) activity that cleaves target nucleic acids. One cardinal rule that is …
Non-coding RNAs from seminal plasma extracellular vesicles and success of live birth among couples undergoing fertility treatment
Background: Infertility remains a global health problem with male-factor infertility accounting
for around 50% of cases. Understanding the molecular markers for the male contribution of …
for around 50% of cases. Understanding the molecular markers for the male contribution of …
DNA-targeting short argonaute triggers effector nuclease to protect bacteria from invaders
M Prostova, A Kanevskaya, V Panteleev, L Lisitskaya… - bioRxiv, 2023 - biorxiv.org
Two prokaryotic defence systems, Argonautes (pAgos) and CRISPR-Cas, detect invader
nucleic acids using complementary guides. Upon recognition, the target is cleaved through …
nucleic acids using complementary guides. Upon recognition, the target is cleaved through …