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Emerging therapeutic strategies for unmet need in neovascular age-related macular degeneration
Neovascular age-related macular degeneration (nAMD) is a major cause of visual
impairment and blindness. Anti-vascular endothelial growth factor (VEGF) agents, such as …
impairment and blindness. Anti-vascular endothelial growth factor (VEGF) agents, such as …
Anti-VEGF-resistant retinal diseases: a review of the latest treatment options
JO Wallsh, RP Gallemore - Cells, 2021 - mdpi.com
Anti-vascular endothelial growth factor (anti-VEGF) therapy currently plays a central role in
the treatment of numerous retinal diseases, most notably exudative age-related macular …
the treatment of numerous retinal diseases, most notably exudative age-related macular …
Mechanisms of macular edema
CD Haydinger, LB Ferreira, KA Williams… - Frontiers in …, 2023 - frontiersin.org
Macular edema is the pathological accumulation of fluid in the central retina. It is a
complication of many retinal diseases, including diabetic retinopathy, retinal vascular …
complication of many retinal diseases, including diabetic retinopathy, retinal vascular …
Update on the management of diabetic retinopathy: Anti-VEGF agents for the prevention of complications and progression of nonproliferative and proliferative …
Diabetic retinopathy (DR) is a microvascular disease caused by poorly controlled blood
glucose, and it is a leading cause of vision loss in people with diabetes. In this review we …
glucose, and it is a leading cause of vision loss in people with diabetes. In this review we …
[HTML][HTML] Nephrotoxicity induced by intravitreal vascular endothelial growth factor inhibitors: emerging evidence
Vascular endothelial growth factor (VEGF) inhibitors have emerged as powerful tools to treat
malignant neoplasms and ocular diseases by virtue of their ability to inhibit angiogenesis …
malignant neoplasms and ocular diseases by virtue of their ability to inhibit angiogenesis …
Intravitreal anti-VEGF agents and cardiovascular risk
M Porta, E Striglia - Internal and emergency medicine, 2020 - Springer
Abstract Antagonists of Vascular Endothelial Growth Factor (Anti-VEGF) are widely
administered by intravitreal injection for the treatment of ocular pathologies such as Age …
administered by intravitreal injection for the treatment of ocular pathologies such as Age …
Phase 1 study of OPT-302 inhibition of vascular endothelial growth factors C and D for neovascular age-related macular degeneration
PU Dugel, DS Boyer, AN Antoszyk, NC Steinle… - Ophthalmology …, 2020 - Elsevier
Purpose OPT-302 is a novel inhibitor of vascular endothelial growth factor (VEGF)-C and
VEGF-D. A phase 1 trial assessed the safety of intravitreal OPT-302 as monotherapy or …
VEGF-D. A phase 1 trial assessed the safety of intravitreal OPT-302 as monotherapy or …
Discovery of aptamers and the acceleration of the development of targeting research in ophthalmology
J Cao, F Zhang, W **ong - International Journal of Nanomedicine, 2023 - Taylor & Francis
Aptamers are widely applied to diagnosis and therapy because of their targeting. However,
the current progress of research into aptamers for the treatment of eye disorders has not …
the current progress of research into aptamers for the treatment of eye disorders has not …
From randomised controlled trials to real-world data: Clinical evidence to guide management of diabetic macular oedema
Randomised clinical trials (RCTs) are generally considered the gold-standard for providing
scientific evidence for treatments' effectiveness and safety but their findings may not always …
scientific evidence for treatments' effectiveness and safety but their findings may not always …
[HTML][HTML] Frequency of intravitreal anti-VEGF injections and risk of death: a systematic review with meta-analysis
Topic To investigate whether an increasing number of intravitreal anti-VEGF injections is
associated with a higher mortality risk. Clinical Relevance The issue of systemic safety of …
associated with a higher mortality risk. Clinical Relevance The issue of systemic safety of …