Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with
devastating public health consequences. While peripheral insulin resistance is a key feature …

Running wheels are commonly employed to measure rodent physical activity in a variety of
contexts, including studies of energy balance and obesity. There is no consensus on the …

In the present study, we investigated whether mild-intensity physical exercise represents a
successful strategy to enhance spatial learning and memory and hippocampal plasticity in …

Current anti-obesity drugs aim to reduce food intake by either curbing appetite or
suppressing the craving for food. However, many of these agents have been associated with …

Aging is associated with impaired cognition and memory and increased susceptibility to
neurodegenerative disorders. Physical exercise is neuroprotective; however, the major …

Insulin resistance is a major risk factor for Alzheimer's disease (AD). Chenodeoxycholic acid
(CDCA) and synthetic Farnesoid X receptor (FXR) ligands have shown promising outcomes …

Ethnopharmacological relevance Many body systems and organs, including the
hippocampus, are affected by diabetes, and undergo changes that may increase the risk of …

Obesity, caused by a high-fat diet (HFD), leads to insulin resistance, which is a precursor of
diabetes and a risk factor for impaired cognitive function, dementia, and brain diseases …

Polyunsaturated fatty acids and antioxidants are important mediators in the central nervous
system. Lipid derivatives may control the production of proinflammatory agents and regulate …

Diabetes mellitus is a metabolic disease associated with dysregulated glucose and insulin
levels and an increased risk of develo** Alzheimer's disease (AD) later in life. It is thought …