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Recent advance in oxazole-based medicinal chemistry
HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
Oxazole and isoxazole: From one-pot synthesis to medical applications
N, O-containing five-membered heterocycles especially oxazole and isoxazole, have widely
been found in many natural products and drugs with relevant medicinal and pharmaceutical …
been found in many natural products and drugs with relevant medicinal and pharmaceutical …
Synthesis and biological evaluation of anti-tubercular activity of Schiff bases of 2-Amino thiazoles
R Cordeiro, M Kachroo - Bioorganic & Medicinal Chemistry Letters, 2020 - Elsevier
Tuberculosis, an infectious disease, has been reported to cause the death of 1.5 million in
2018. Due to the emergence of Multi-Drug Resistant-TB, Extensively Drug Resistant-TB, and …
2018. Due to the emergence of Multi-Drug Resistant-TB, Extensively Drug Resistant-TB, and …
Microwave irradiated one pot, three component synthesis of a new series of hybrid coumarin based thiazoles: Antibacterial evaluation and molecular docking studies
A series of new coumarin based thiazoles were synthesized by the microwave irradiation of
thiocarbohydrazide, aldehydes and 3-(2-bromoacetyl) coumarins. Structures of all the …
thiocarbohydrazide, aldehydes and 3-(2-bromoacetyl) coumarins. Structures of all the …
Visible light‐mediated photocatalyzed synthesis of oxazole via intermolecular C N and C O bond formation
An efficient visible light‐mediated, eosin Y‐catalyzed synthesis of oxazole has been
developed from benzil with primary amines, that providing a straightforward, green, and …
developed from benzil with primary amines, that providing a straightforward, green, and …
Thiazolyl-pyrazole derivatives as potential antimycobacterial agents
Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …
Synthesis of new thiazolyl-pyrazolyl-1, 2, 3-triazole derivatives as potential antimicrobial agents
A series of 1-substituted benzyl-4-[1-phenyl-3-(4-methyl-2-aryl-1, 3-thiazol-5-yl)-1H-pyrazol-
4-yl]-1H-1, 2, 3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4 …
4-yl]-1H-1, 2, 3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4 …
[HTML][HTML] Recent advances in the synthesis of oxazole-based molecules via van leusen oxazole synthesis
X Zheng, W Liu, D Zhang - Molecules, 2020 - mdpi.com
Oxazole compounds, including one nitrogen atom and one oxygen atom in a five-membered
heterocyclic ring, are present in various biological activities. Due to binding with a …
heterocyclic ring, are present in various biological activities. Due to binding with a …
Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives
The increase in antibiotic resistance due to multiple factors has warranted the need for
search of new compounds which are active against multidrug resistant pathogens. In this …
search of new compounds which are active against multidrug resistant pathogens. In this …
Synthesis of novel oxazol-5-one derivatives containing chiral trifluoromethyl and isoxazole moieties as potent antitumor agents and the mechanism investigation
M Wang, L Li, S Yang, F Guo, G Zhu, B Zhu… - Bioorganic Chemistry, 2023 - Elsevier
In this study, a series of novel oxazol-5-one derivatives containing a chiral trifluoromethyl
and isoxazole moiety were synthesized and evaluated for cytotoxic activities. Among them …
and isoxazole moiety were synthesized and evaluated for cytotoxic activities. Among them …