Recent advance in oxazole-based medicinal chemistry

HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

Oxazole and isoxazole: From one-pot synthesis to medical applications

A Thakur, M Verma, R Bharti, R Sharma - Tetrahedron, 2022 - Elsevier
N, O-containing five-membered heterocycles especially oxazole and isoxazole, have widely
been found in many natural products and drugs with relevant medicinal and pharmaceutical …

Synthesis and biological evaluation of anti-tubercular activity of Schiff bases of 2-Amino thiazoles

R Cordeiro, M Kachroo - Bioorganic & Medicinal Chemistry Letters, 2020 - Elsevier
Tuberculosis, an infectious disease, has been reported to cause the death of 1.5 million in
2018. Due to the emergence of Multi-Drug Resistant-TB, Extensively Drug Resistant-TB, and …

Microwave irradiated one pot, three component synthesis of a new series of hybrid coumarin based thiazoles: Antibacterial evaluation and molecular docking studies

S Mamidala, SR Peddi, RK Aravilli, PC Jilloju… - Journal of Molecular …, 2021 - Elsevier
A series of new coumarin based thiazoles were synthesized by the microwave irradiation of
thiocarbohydrazide, aldehydes and 3-(2-bromoacetyl) coumarins. Structures of all the …

Visible light‐mediated photocatalyzed synthesis of oxazole via intermolecular C N and C O bond formation

MZ Beg, S Tivari, A Kashyap, PK Singh… - Journal of …, 2024 - Wiley Online Library
An efficient visible light‐mediated, eosin Y‐catalyzed synthesis of oxazole has been
developed from benzil with primary amines, that providing a straightforward, green, and …

Thiazolyl-pyrazole derivatives as potential antimycobacterial agents

SJ Takate, AD Shinde, BK Karale, H Akolkar… - Bioorganic & Medicinal …, 2019 - Elsevier
Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …

Synthesis of new thiazolyl-pyrazolyl-1, 2, 3-triazole derivatives as potential antimicrobial agents

J Nalawade, A Shinde, A Chavan, S Patil… - European journal of …, 2019 - Elsevier
A series of 1-substituted benzyl-4-[1-phenyl-3-(4-methyl-2-aryl-1, 3-thiazol-5-yl)-1H-pyrazol-
4-yl]-1H-1, 2, 3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4 …

[HTML][HTML] Recent advances in the synthesis of oxazole-based molecules via van leusen oxazole synthesis

X Zheng, W Liu, D Zhang - Molecules, 2020 - mdpi.com
Oxazole compounds, including one nitrogen atom and one oxygen atom in a five-membered
heterocyclic ring, are present in various biological activities. Due to binding with a …

Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives

YK Abhale, A Shinde, KK Deshmukh, L Nawale… - Medicinal Chemistry …, 2017 - Springer
The increase in antibiotic resistance due to multiple factors has warranted the need for
search of new compounds which are active against multidrug resistant pathogens. In this …

Synthesis of novel oxazol-5-one derivatives containing chiral trifluoromethyl and isoxazole moieties as potent antitumor agents and the mechanism investigation

M Wang, L Li, S Yang, F Guo, G Zhu, B Zhu… - Bioorganic Chemistry, 2023 - Elsevier
In this study, a series of novel oxazol-5-one derivatives containing a chiral trifluoromethyl
and isoxazole moiety were synthesized and evaluated for cytotoxic activities. Among them …