The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Synthetic lethality (SL) provides a conceptual framework for tackling targets that are not
classically “druggable,” including loss-of-function mutations in tumor suppressor genes …

Intestinal organoids grown from adult stem cells have emerged as prototype 3D organotypic
models for studying tissue renewal and homeostasis. Owing to their strict dependence on …

The gastrointestinal (GI) tract is a complex system responsible for nutrient absorption,
digestion, secretion, and elimination of waste products that also hosts immune surveillance …

Three-dimensional organoids have been widely used for developmental and disease
modeling. Organoids are derived from both adult and pluripotent stem cells. Various types …

The tumour suppressors RNF43 and ZNRF3 play a central role in development and tissue
homeostasis by promoting the turnover of the Wnt receptors LRP6 and Frizzled (FZD). The …

Synthetic lethality is a genetic phenomenon whereby the simultaneous presence of two
different genetic alterations impairs cellular viability. Importantly, targeting synthetic lethal …

Wnt-induced β-catenin-mediated transcription is a driving force for stem cell self-renewal
during adult tissue homeostasis. Enhanced Wnt receptor expression due to mutational …

High grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is the
deadliest gynecological disease which results in a five-year survival rate of 30% or less …

Due to the complex function and structure of the liver, resourceful solutions for treating end-
stage liver disease are required. Currently, liver transplantation is the only curative …