Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …

To cope with the reduced availability of O2 at high altitude, air-breathing vertebrates have
evolved myriad adjustments in the cardiorespiratory system to match tissue O2 delivery with …

Epistatic interactions can make the outcomes of evolution unpredictable, but no
comprehensive data are available on the extent and temporal dynamics of changes in the …

The genetic architecture of adaptive traits is of key importance to predict evolutionary
responses. Most adaptive traits are polygenic—ie, result from selection on a large number of …

A core question in evolutionary biology is whether convergent phenotypic evolution is driven
by convergent molecular changes in proteins or regulatory regions. We combined …

To understand why molecular evolution turned out as it did, we must characterize not only
the path that evolution followed across the space of possible molecular sequences but also …

Currently, cell membrane is always utilized for the construction of biomimetic nanoparticles.
By contrast, mimicking the intracellular activity seems more meaningful. Inspired by the …

Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthesis
that has evolved independently many times in diverse lineages of flowering plants. We …

Proteins are molecular machines composed of complex, highly connected amino acid
networks. Their functional optimization requires the reorganization of these intramolecular …

Convergent evolution in the genomics era: new insights and directions | Philosophical
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