Polyhydroxylated alkaloids—natural occurrence and therapeutic applications

AA Watson, GWJ Fleet, N Asano, RJ Molyneux… - Phytochemistry, 2001 - Elsevier
Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-
organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and …

Iminosugars as therapeutic agents: recent advances and promising trends

RJ Nash, A Kato, CY Yu, GWJ Fleet - Future Medicinal Chemistry, 2011 - Taylor & Francis
For the purpose of this article, iminosugars are polyhydroxylated secondary and tertiary
amines in which the molecules resemble monosaccharide sugars in which the ring oxygen …

Nitrile oxides

V Jäger, PA Colinas - Synthetic Applications of 1, 3‐Dipolar …, 2002 - Wiley Online Library
This chapter outlines the progress in nitrile oxide cycloadditions and synthetic uses of the
cycloadducts over the past 20 years. A liberal choice of examples involving important new …

Polyhydroxylated Alkaloids Isolated from Mulberry Trees (Morus alba L.) and Silkworms (Bombyx mori L.)

N Asano, T Yamashita, K Yasuda, K Ikeda… - Journal of agricultural …, 2001 - ACS Publications
New polyhydroxylated alkaloids,(2 R, 3 R, 4 R)-2-hydroxymethyl-3, 4-dihydroxypyrrolidine-N-
propionamide from the root bark of Morus alba L., and 4-O-α-d-galactopyranosyl-calystegine …

N-containing sugars fromMorus alba and their glycosidase inhibitory activities

N Asano, K Oseki, E Tomioka, H Kizu, K Matsui - Carbohydrate research, 1994 - Elsevier
The reexamination ofN-containing sugars from the roots ofMorus alba by improved
purification procedures led to the isolation of eighteenN-containing sugars, including seven …

Sugars with nitrogen in the ring isolated from the leaves of Morus bombycis

N Asano, E Tomioka, H Kizu, K Matsui - Carbohydrate research, 1994 - Elsevier
It is known that 1-deoxynojirimycin (1) is contained in the leaves and roots of Morus sp. The
modified purification procedures of 1 from leaves of Morus bombycis led to the isolation of …

Inhibition of HIV replication by amino‐sugar derivatives

GWJ Fleet, A Karpas, RA Dwek, LE Fellows… - FEBS …, 1988 - Wiley Online Library
The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and
deoxynojirimycin have recently been shown to have potential anti‐HIV activity [(1987) Proc …

Iminosugars and relatives as antiviral and potential anti-infective agents

P Greimel, J Spreitz, AE Stutz… - Current topics in …, 2003 - ingentaconnect.com
Iminosugars have emerged in the literature during mid-1960's as synthetic compounds.
Around the same time, the first examples were found in Nature and their interesting enzyme …

Recent advances in the chemistry of azapyranose sugars

K Afarinkia, A Bahar - Tetrahedron: Asymmetry, 2005 - Elsevier
Recent advances in the chemistry of azapyranose sugars - ScienceDirect Skip to main
contentSkip to article Elsevier logo Journals & Books Search RegisterSign in View PDF …

N-Substituted l-Iminosugars for the Treatment of Sanfilippo Type B Syndrome

V De Pasquale, A Esposito, G Scerra… - Journal of Medicinal …, 2023 - ACS Publications
Sanfilippo syndrome comprises a group of four genetic diseases due to the lack or
decreased activity of enzymes involved in heparan sulfate (HS) catabolism. HS …