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Strategies for improving the payload of small molecular drugs in polymeric micelles
Y Zhang, T Ren, J Gou, L Zhang, X Tao, B Tian… - Journal of Controlled …, 2017 - Elsevier
In the past few years, substantial efforts have been made in the design and preparation of
polymeric micelles as novel drug delivery vehicles. Typically, polymeric micelles possess a …
polymeric micelles as novel drug delivery vehicles. Typically, polymeric micelles possess a …
How successful is nuclear targeting by nanocarriers?
The nucleus is ultimately the final target for many therapeutics treating various disorders
including cancers, heart dysfunction and brain disorders. Owing to their specialized cell …
including cancers, heart dysfunction and brain disorders. Owing to their specialized cell …
Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancer
Abstract Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that generates
NADPH to maintain reduced glutathione (GSH), which scavenges reactive oxygen species …
NADPH to maintain reduced glutathione (GSH), which scavenges reactive oxygen species …
Drug and gene co-delivery systems for cancer treatment
Cancer remains a major killer and a leading cause of death in the world; thus, a growing
number of new treatments have been focused on cancer therapy over the past few decades …
number of new treatments have been focused on cancer therapy over the past few decades …
Recent advances in the synthesis of biodegradable polyesters by sustainable polymerization: lipase-catalyzed polymerization
Over the past three decades, enzymatic polymerization has dramatically developed and
gradually broadened as a creative methodology in the construction of polymeric materials …
gradually broadened as a creative methodology in the construction of polymeric materials …
Ultrasound-triggered phase-transition cationic nanodroplets for enhanced gene delivery
Ultrasound as an external stimulus for enhanced gene transfection represents a safe,
noninvasive, cost-effective delivery strategy for gene therapy. Herein, we have developed an …
noninvasive, cost-effective delivery strategy for gene therapy. Herein, we have developed an …
A copper-mediated disulfiram-loaded pH-triggered PEG-shedding TAT peptide-modified lipid nanocapsules for use in tumor therapy
L Zhang, B Tian, Y Li, T Lei, J Meng… - … applied materials & …, 2015 - ACS Publications
Disulfiram, which exhibits marked tumor inhibition mediated by copper, was encapsulated in
lipid nanocapsules modified with TAT peptide (TATp) and pH-triggered sheddable PEG to …
lipid nanocapsules modified with TAT peptide (TATp) and pH-triggered sheddable PEG to …
Dual-targeting hybrid nanoparticles for the delivery of SN38 to Her2 and CD44 overexpressed human gastric cancer
Gastric cancer (GC), particularly of the type with high expression of both human epidermal
growth factor receptor 2 (Her2) and cluster determinant 44 (CD44), is one of the most …
growth factor receptor 2 (Her2) and cluster determinant 44 (CD44), is one of the most …
Enzymatic PEG-Poly(amine-co-disulfide ester) Nanoparticles as pH- and Redox-Responsive Drug Nanocarriers for Efficient Antitumor Treatment
Y Chen, M Su, Y Li, J Gao, C Zhang… - … Applied Materials & …, 2017 - ACS Publications
We have designed and constructed novel multifunctional nanoparticle drug-delivery systems
that are stable under physiological conditions and responsive to tumor-relevant pH and …
that are stable under physiological conditions and responsive to tumor-relevant pH and …
Non-viral vectors based on cationic niosomes as efficient gene delivery vehicles to central nervous system cells into the brain
Abstract Development of safe and efficient non-viral vectors to deliver DNA into the CNS
represents a huge challenge to face many neurological disorders. We elaborated niosomes …
represents a huge challenge to face many neurological disorders. We elaborated niosomes …