Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives

S Shen, C Zhan, C Yang, AR Fernie, J Luo - Molecular Plant, 2023 - cell.com
Plants are natural experts in organic synthesis, being able to generate large numbers of
specific metabolites with widely varying structures that help them adapt to variable survival …

Managing land carrying capacity: Key to achieving sustainable production systems for food security

X Wang - Land, 2022 - mdpi.com
Many previous studies have estimated the carrying capacity and feasible planetary
boundaries for humankind. However, less attention has been given to how we will …

The gut microbiome contributes to a substantial proportion of the variation in blood lipids

J Fu, MJ Bonder, MC Cenit, EF Tigchelaar… - Circulation …, 2015 - Am Heart Assoc
Rationale: Evidence suggests that the gut microbiome is involved in the development of
cardiovascular disease, with the host–microbe interaction regulating immune and metabolic …

Metabolomics in the context of plant natural products research: From sample preparation to metabolite analysis

MA Salem, L Perez de Souza, A Serag, AR Fernie… - Metabolites, 2020 - mdpi.com
Plant-derived natural products have long been considered a valuable source of lead
compounds for drug development. Natural extracts are usually composed of hundreds to …

Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism

W Chen, Y Gao, W **e, L Gong, K Lu, W Wang, Y Li… - Nature …, 2014 - nature.com
Plant metabolites are important to world food security in terms of maintaining sustainable
yield and providing food with enriched phytonutrients. Here we report comprehensive …

The flavonoid biosynthetic pathway in Arabidopsis: structural and genetic diversity

K Saito, K Yonekura-Sakakibara… - Plant Physiology and …, 2013 - Elsevier
Flavonoids are representative plant secondary products. In the model plant Arabidopsis
thaliana, at least 54 flavonoid molecules (35 flavonols, 11 anthocyanins and 8 …

Metabolomics 20 years on: what have we learned and what hurdles remain?

S Alseekh, AR Fernie - The Plant Journal, 2018 - Wiley Online Library
The term metabolome was coined in 1998, by analogy to genome, transcriptome and
proteome. The first research papers using the terms metabolomics, metabonomics …

Systematic error removal using random forest for normalizing large-scale untargeted lipidomics data

S Fan, T Kind, T Cajka, SL Hazen, WHW Tang… - Analytical …, 2019 - ACS Publications
Large-scale untargeted lipidomics experiments involve the measurement of hundreds to
thousands of samples. Such data sets are usually acquired on one instrument over days or …

An InDel in the Promoter of Al-ACTIVATED MALATE TRANSPORTER9 Selected during Tomato Domestication Determines Fruit Malate Contents and Aluminum …

J Ye, X Wang, T Hu, F Zhang, B Wang, C Li… - The Plant …, 2017 - academic.oup.com
Deciphering the mechanism of malate accumulation in plants would contribute to a greater
understanding of plant chemistry, which has implications for improving flavor quality in crop …

Metabolome-based genome-wide association study of maize kernel leads to novel biochemical insights

W Wen, D Li, X Li, Y Gao, W Li, H Li, J Liu, H Liu… - Nature …, 2014 - nature.com
Plants produce a variety of metabolites that have a critical role in growth and development.
Here we present a comprehensive study of maize metabolism, combining genetic …