Randomized controlled trials (RCTs) are conducted under idealized and rigorously
controlled conditions that may compromise their external validity. A literature review was …

With the emergence of individualized medicine and the increasing amount and complexity of
available medical data, a growing need exists for the development of clinical decision …

Background Near-infrared spectroscopy (NIRS) and intravascular ultrasound are promising
imaging modalities to identify non-obstructive plaques likely to cause coronary-related …

When treatment effect modifiers influence the decision to participate in a randomized trial,
the average treatment effect in the population represented by the randomized individuals …

Background Patients with acute myocardial infarction (MI) are at risk for develo** heart
failure (HF) and subsequently are at an increased risk of mortality. Sodium-glucose …

Abstract “Site selection bias” can occur when the probability that a program is adopted or
evaluated is correlated with its impacts. I test for site selection bias in the context of the …

Objective This study aimed to assess the impact of individual comorbid conditions as well as
the weight assignment, predictive properties and discriminating power of the Charlson …

Background The relative vaccine effectiveness (rVE) of high-dose quadrivalent influenza
vaccines (QIV-HD) versus standard-dose quadrivalent influenza vaccines (QIV-SD) against …

Background—Uncertainty remains over optimal antithrombotic treatment of patients with
atrial fibrillation presenting with myocardial infarction and/or undergoing percutaneous …

Background—The optimal long-term antithrombotic treatment of patients with coexisting
atrial fibrillation and stable coronary artery disease is unresolved, and commonly, a single …