Macrophage migration inhibitory factor (MIF): a multifaceted cytokine regulated by genetic and physiological strategies

K Sumaiya, D Langford, K Natarajaseenivasan… - Pharmacology & …, 2022 - Elsevier
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …

Hallmarks of aging in macrophages: consequences to skin inflammaging

GR Guimarães, PP Almeida, L de Oliveira Santos… - Cells, 2021 - mdpi.com
The skin is our largest organ and the outermost protective barrier. Its aging reflects both
intrinsic and extrinsic processes resulting from the constant insults it is exposed to. Aging in …

Restraint stress promotes monobenzone-induced depigmentation in mice via the activation of glucocorticoid receptor/macrophage migration inhibitory factor signaling …

N Tang, XT Liu, WL Wen, TS Liang, XT Lv, QL Li… - Molecular …, 2023 - Elsevier
Psychological stress triggers onset and development of vitiligo in humans. However, the
mechanism of psychological stress on vitiligo remains unclear. The study aims to investigate …

MIF inhibition alleviates vitiligo progression by suppressing CD8+ T cell activation and proliferation

J Chen, W Guo, P Du, T Cui, Y Yang… - The Journal of …, 2023 - Wiley Online Library
In vitiligo, autoreactive CD8+ T cells have been established as the main culprit considering
its pathogenic role in mediating epidermal melanocyte‐specific destruction. Macrophage …

Comprehensive analysis of cell population dynamics and related core genes during vitiligo development

J Zhang, S Yu, W Hu, M Wang, D Abudoureyimu… - Frontiers in …, 2021 - frontiersin.org
Vitiligo is a common immune-related depigmentation condition, and its pathogenesis
remains unclear. This study used a combination of bioinformatics methods and expression …

Prevalence and burden of vitiligo in Africa, the Middle East and Latin America

A Al Hammadi, CC Silva de Castro… - Skin Health and …, 2024 - Wiley Online Library
Vitiligo is a common chronic autoimmune disorder characterized by skin and hair
depigmentation that affects 0.5%–2.0% of the global population. Vitiligo is associated with …

Increased Expression of Long Noncoding RNA LOC100506314 in T cells from Patients with Nonsegmental Vitiligo and Its Contribution to Vitiligo Pathogenesis

NS Lai, HC Yu, HB Huang… - Mediators of …, 2023 - Wiley Online Library
This study aimed to identify the abnormal expression of long noncoding RNAs (lncRNAs) in
T cells from patients with vitiligo and to investigate their functional roles in the immune …

The Role of Regulatory Cell Death in Vitiligo

LY Liu, SJ He, Z Chen, M Ge, CY Lyu, D Gao… - DNA and Cell …, 2024 - liebertpub.com
Vitiligo is one of the common chronic autoimmune skin diseases in clinic, which is
characterized by localized or generalized depigmentation and seriously affects the physical …

Erzhiwan Ameliorates Restraint Stress-and Monobenzone-Induced Depigmentation in Mice by Inhibiting Macrophage Migration Inhibitory Factor and 8-Hydroxy-2 …

N Tang, XT Liu, XL Lin, WX Yang, QL Li… - Clinical, Cosmetic …, 2024 - Taylor & Francis
Purpose Vitiligo is an autoimmune disease that results in the loss of epidermal melanocytes.
The treatments for patients with vitiligo remain lacking. Erzhiwan (EZW), a traditional …

Macrophage Migration Inhibitory Factor and Gene Polymorphism (rs755622G> C) in Unstable Vitiligo Patients

HM Ibrahim, MH Hassan, MA El-Taieb… - Dermatologic …, 2023 - Wiley Online Library
Vitiligo pathogenesis is related to the macrophage migration inhibitory factor (MIF) protein.
This study aimed to assess the lesional MIF levels and gene polymorphisms (rs755622G> …