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mRNA-based therapeutics: looking beyond COVID-19 vaccines
H Parhiz, EN Atochina-Vasserman, D Weissman - The Lancet, 2024 - thelancet.com
Recent advances in mRNA technology and its delivery have enabled mRNA-based
therapeutics to enter a new era in medicine. The rapid, potent, and transient nature of mRNA …
therapeutics to enter a new era in medicine. The rapid, potent, and transient nature of mRNA …
Prevention, treatment and cure of HIV infection
The development of antiretroviral therapy for the prevention and treatment of HIV infection
has been marked by a series of remarkable successes. However, the efforts to develop a …
has been marked by a series of remarkable successes. However, the efforts to develop a …
Immunological memory diversity in the human upper airway
The upper airway is an important site of infection, but immune memory in the human upper
airway is poorly understood, with implications for COVID-19 and many other human …
airway is poorly understood, with implications for COVID-19 and many other human …
Vaccination induces broadly neutralizing antibody precursors to HIV gp41
A key barrier to the development of vaccines that induce broadly neutralizing antibodies
(bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic …
(bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic …
Recent progress in mRNA cancer vaccines
R Yao, C **e, X **a - Human Vaccines & Immunotherapeutics, 2024 - Taylor & Francis
The research and development of messenger RNA (mRNA) cancer vaccines have gradually
overcome numerous challenges through the application of personalized cancer antigens …
overcome numerous challenges through the application of personalized cancer antigens …
Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site
Eliciting potent and broadly neutralizing antibodies (bnAbs) is a major goal in HIV-1 vaccine
development. Here, we describe how germline-targeting immunogen BG505 SOSIP …
development. Here, we describe how germline-targeting immunogen BG505 SOSIP …
mRNA vaccines: The future of prevention of viral infections?
Messenger RNA (mRNA) vaccines against COVID‐19 are the first authorized biological
preparations developed using this platform. During the pandemic, their administration has …
preparations developed using this platform. During the pandemic, their administration has …
A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses
The engineered outer domain germline targeting version 8 (eOD-GT8) 60-mer nanoparticle
was designed to prime VRC01-class HIV-specific B cells that would need to be matured …
was designed to prime VRC01-class HIV-specific B cells that would need to be matured …
Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates
Germline-targeting immunogens hold promise for initiating the induction of broadly
neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen …
neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen …
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models
Germline-targeting (GT) protein immunogens to induce VRC01-class broadly neutralizing
antibodies (bnAbs) to the CD4-binding site of the HIV envelope (Env) have shown promise …
antibodies (bnAbs) to the CD4-binding site of the HIV envelope (Env) have shown promise …