Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells
continue division before acquiring a fully differentiated state, while terminal differentiation …

Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Suboptimal functional persistence limits the efficacy of adoptive T-cell therapies. CD28-
based chimeric antigen receptors (CAR) impart potent effector function to T cells but with a …

Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to
external cues to regulate the many uses of DNA. A principle component of chromatin that …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Posttranslational modifications of histone N-terminal tails impact chromatin structure and
gene transcription. While the extent of histone acetylation is determined by both …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Cellular senescence is an extremely stable form of cell cycle arrest that limits the
proliferation of damaged cells and may act as a natural barrier to cancer progression. In this …