The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …

The cardiac extracellular matrix (ECM) not only provides mechanical support, but also
transduces essential molecular signals in health and disease. Following myocardial …

The localization and accumulation of drugs in the body determine their therapeutic effects;
however, the specific microstructure of damaged tissues hinders drug delivery. Currently …

Cysteine cathepsins have been for a long time considered to execute mainly nonspecific
bulk proteolysis in the endolysosomal system. However, this view has been changing …

The extracellular matrix (ECM) surrounding cells is indispensable for regulating their
behavior. The dynamics of ECM signaling are tightly controlled throughout growth and …

Recent research has highlighted the importance of key tumor microenvironment features,
notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and …

Kidney fibrosis initiates at certain focal sites in which the fibrogenic niche provides a
specialized microenvironment that facilitates fibroblast activation and proliferation. However …

The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …