Major progress has been made in recent years in the development of Hedgehog (Hh)
pathway inhibitors for the treatment of patients with cancer. Promising clinical trial results …

The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in
embryonic patterning and development. Since its discovery, it has become increasingly …

Primary cilia are microtubule-based organelles that extend from the apical surface of most
mammalian cells, forming when the basal body (derived from the mother centriole) docks at …

Oxysterols bind the seven-transmembrane protein Smo (Smo) and potently activate
vertebrate Hedgehog (Hh) signaling, a pathway essential in embryonic development, adult …

Background: The primary cilium is a singular cellular structure that extends from the surface
of many cell types and plays crucial roles in vertebrate development, including that of the …

Over the past two decades, the secreted protein sonic hedgehog (SHH) has emerged as a
critical morphogen during embryonic lung development, regulating the interaction between …

Hedgehog (Hh) is first described as a genetic mutation that has “spiked” phenotype in the
cuticles of Drosophila in later 1970s. Since then, Hh signaling has been implicated in …

Obesity and diabetes represent key healthcare challenges of our day, affecting upwards of
one billion people worldwide. These individuals are at higher risk for cancer, stroke …

The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein
Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology …

Abstract The Hedgehog (Hh) pathway has become an important model to study the cell
biology of primary cilia, and reciprocally, the study of ciliary processes provides an …