Abstract Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase, has proven beneficial preventive effects on cardiovascular events. However …

HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all
medications, have potential for adverse effects (AEs). Here we review the statin AE literature …

Background Lowering of LDL cholesterol with standard statin regimens reduces the risk of
occlusive vascular events in a wide range of individuals. We aimed to assess the safety and …

Background Lowering of LDL cholesterol with standard statin regimens reduces the risk of
occlusive vascular events in a wide range of individuals. We aimed to assess the safety and …

Statin therapy is generally well tolerated and very effective in the prevention and treatment of
cardiovascular disease, regardless of cholesterol levels; however, it can be associated with …

Background—Our objective was to estimate the comparative harms of individual statins
using both placebo-controlled and active-comparator trials. Methods and Results—We …

Objective To quantify the unintended effects of statins according to type, dose, and duration
of use. Design Prospective open cohort study using routinely collected data. Setting 368 …

Background Statins have been shown to reduce the risk of all-cause mortality among
individuals with clinical history of coronary heart disease. However, it remains uncertain …

Background Familial hypercholesterolemia is one of the most common inherited metabolic
diseases and is an autosomal dominant disorder meaning heterozygotes, or carriers, are …

There are currently several different classes of drugs available for lowering cholesterol
levels. There are currently seven HMG-CoA reductase inhibitors (statins) approved for …