Principles and methods for transferring polygenic risk scores across global populations

L Kachuri, N Chatterjee, J Hirbo, DJ Schaid… - Nature Reviews …, 2024 - nature.com
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …

Single-cell genomics meets human genetics

ASE Cuomo, A Nathan, S Raychaudhuri… - Nature Reviews …, 2023 - nature.com
Single-cell genomic technologies are revealing the cellular composition, identities and
states in tissues at unprecedented resolution. They have now scaled to the point that it is …

Promoting equity in polygenic risk assessment through global collaboration

IJ Kullo - Nature Genetics, 2024 - nature.com
The long delay before genomic technologies become available in low-and middle-income
countries is a concern from both scientific and ethical standpoints. Polygenic risk scores …

Community partnerships are fundamental to ethical ancient DNA research

E Kowal, LS Weyrich, JM Argüelles, AC Bader… - Human Genetics and …, 2023 - cell.com
The ethics of the scientific study of Ancestors has long been debated by archaeologists,
bioanthropologists, and, more recently, ancient DNA (aDNA) researchers. This article …

[PDF][PDF] Evolutionary genetics and admixture in African populations

A Pfennig, LN Petersen, P Kachambwa… - Genome Biology and …, 2023 - academic.oup.com
As the ancestral homeland of our species, Africa contains elevated levels of genetic diversity
and substantial population structure. Importantly, African genomes are heterogeneous: They …

[HTML][HTML] Addressing the challenges of polygenic scores in human genetic research

J Novembre, C Stein, S Asgari… - The American Journal of …, 2022 - cell.com
The genoty** of millions of human samples has made it possible to evaluate variants
across the human genome for their possible association with risks for numerous diseases …

Consideration and disclosure of group risks in genomics and other data-centric research: Does the common rule need revision?

CR Chapman, GP Quinn, HM Natri… - The American Journal …, 2023 - Taylor & Francis
Harms and risks to groups and third-parties can be significant in the context of research,
particularly in data-centric studies involving genomic, artificial intelligence, and/or machine …

Extending an antiracism lens to the implementation of precision public health interventions

CG Allen, DL Olstad, AR Kahkoska… - … Journal of Public …, 2023 - ajph.aphapublications.org
Precision public health holds promise to improve disease prevention and health promotion
strategies, allowing the right intervention to be delivered to the right population at the right …

[HTML][HTML] Do people with hereditary cancer syndromes inform their at-risk relatives? A systematic review and meta-analysis

MD Ahsan, SR Levi, EM Webster, H Bergeron, J Lin… - PEC innovation, 2023 - Elsevier
Purpose To evaluate rates of familial disclosure of hereditary cancer syndrome information.
Methods A systematic review and meta-analysis was conducted in accordance with PRISMA …

Publics' knowledge of, attitude to and motivation towards health-related genomics: a sco** review

A Pearce, LA Mitchell, S Best, MA Young… - European Journal of …, 2024 - nature.com
The use of genomic data in research and genomic information in clinical care is increasing
as technologies advance and sequencing costs decrease. Using Rogers' Diffusion of …