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Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Single-cell genomics meets human genetics
Single-cell genomic technologies are revealing the cellular composition, identities and
states in tissues at unprecedented resolution. They have now scaled to the point that it is …
states in tissues at unprecedented resolution. They have now scaled to the point that it is …
Promoting equity in polygenic risk assessment through global collaboration
IJ Kullo - Nature Genetics, 2024 - nature.com
The long delay before genomic technologies become available in low-and middle-income
countries is a concern from both scientific and ethical standpoints. Polygenic risk scores …
countries is a concern from both scientific and ethical standpoints. Polygenic risk scores …
Community partnerships are fundamental to ethical ancient DNA research
The ethics of the scientific study of Ancestors has long been debated by archaeologists,
bioanthropologists, and, more recently, ancient DNA (aDNA) researchers. This article …
bioanthropologists, and, more recently, ancient DNA (aDNA) researchers. This article …
[PDF][PDF] Evolutionary genetics and admixture in African populations
A Pfennig, LN Petersen, P Kachambwa… - Genome Biology and …, 2023 - academic.oup.com
As the ancestral homeland of our species, Africa contains elevated levels of genetic diversity
and substantial population structure. Importantly, African genomes are heterogeneous: They …
and substantial population structure. Importantly, African genomes are heterogeneous: They …
[HTML][HTML] Addressing the challenges of polygenic scores in human genetic research
The genoty** of millions of human samples has made it possible to evaluate variants
across the human genome for their possible association with risks for numerous diseases …
across the human genome for their possible association with risks for numerous diseases …
Consideration and disclosure of group risks in genomics and other data-centric research: Does the common rule need revision?
Harms and risks to groups and third-parties can be significant in the context of research,
particularly in data-centric studies involving genomic, artificial intelligence, and/or machine …
particularly in data-centric studies involving genomic, artificial intelligence, and/or machine …
Extending an antiracism lens to the implementation of precision public health interventions
Precision public health holds promise to improve disease prevention and health promotion
strategies, allowing the right intervention to be delivered to the right population at the right …
strategies, allowing the right intervention to be delivered to the right population at the right …
[HTML][HTML] Do people with hereditary cancer syndromes inform their at-risk relatives? A systematic review and meta-analysis
Purpose To evaluate rates of familial disclosure of hereditary cancer syndrome information.
Methods A systematic review and meta-analysis was conducted in accordance with PRISMA …
Methods A systematic review and meta-analysis was conducted in accordance with PRISMA …
Publics' knowledge of, attitude to and motivation towards health-related genomics: a sco** review
The use of genomic data in research and genomic information in clinical care is increasing
as technologies advance and sequencing costs decrease. Using Rogers' Diffusion of …
as technologies advance and sequencing costs decrease. Using Rogers' Diffusion of …