Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Advances in sequencing techniques and statistical methods have made it possible not only
to predict sequences of ancestral proteins but also to identify thousands of mutations in the …

How disease-associated mutations impair protein activities in the context of biological
networks remains mostly undetermined. Although a few renowned alleles are well …

Functional diversity of the highly polymorphic human leukocyte antigen class I (HLA-I) genes
underlies successful immunologic control of both infectious disease and cancer. The …

Abstract The Human Gene Mutation Database (HGMD®) is a comprehensive core collection
of germline mutations in nuclear genes that underlie or are associated with human inherited …

Urbanization drastically transforms landscapes, resulting in fragmentation, degradation, and
the loss of local biodiversity. Yet, urban environments also offer opportunities to observe …

Quantifying the distribution of fitness effects among newly arising mutations in the human
genome is key to resolving important debates in medical and evolutionary genetics. Here …

Cellular functions are mediated through complex systems of macromolecules and
metabolites linked through biochemical and physical interactions, represented in …

Many disease-causing missense mutations affect intrinsically disordered regions (IDRs) of
proteins, but the molecular mechanism of their pathogenicity is enigmatic. Here, we employ …

This article describes a set of alignments of 28 vertebrate genome sequences that is
provided by the UCSC Genome Browser. The alignments can be viewed on the Human …