Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …

Conventional cancer therapies suffer from severe off-target effects because most of them
target critical facets of cells that are generally shared by all rapidly proliferating cells. The …

Copper serves as a co-factor for a host of metalloenzymes that contribute to malignant
progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has …

Copper homeostasis is strictly regulated by protein transporters and chaperones, to allow its
correct distribution and avoid uncontrolled redox reactions. Several studies address copper …

Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …

Background Ovarian cancer (OC) is one of the most common and most malignant
gynecological malignancies in gynecology. On the other hand, dysregulation of copper …

Cancer incidence is rising and this global challenge is further exacerbated by tumour
resistance to available medicines. A promising approach to meet the need for improved …

Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …

The antitumor activity of disulfiram (DSF), a traditional US Food and Drug Administration-
approved drug for the treatment of “alcohol-dependence”, is Cu2+-dependent, but the …

The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …