Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

A Grifoni, T Alonzi, G Alter, DMC Noonan… - Frontiers in …, 2023 - frontiersin.org
Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …

Monocyte subsets: phenotypes and function in tuberculosis infection

P Sampath, K Moideen, UD Ranganathan… - Frontiers in …, 2018 - frontiersin.org
Monocytes are critical defense components that play an important role in the primary innate
immune response. The heterogeneous nature of monocytes and their ability to differentiate …

Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny

L Huang, EV Nazarova, S Tan, Y Liu… - Journal of Experimental …, 2018 - rupress.org
Under homeostatic conditions, macrophages derived from different ontogenies coexist in
many tissues. In these situations, it is unclear the extent to which macrophage origin versus …

Update on tuberculosis biomarkers: from correlates of risk, to correlates of active disease and of cure from disease

D Goletti, MR Lee, JY Wang, N Walter… - …, 2018 - Wiley Online Library
Tuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global
health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB‐BM) would …

Associations between nutritional and immune status and clinicopathologic factors in patients with tuberculosis: A comprehensive analysis

QX Liu, DY Tang, X **ang, JQ He - Frontiers in cellular and infection …, 2022 - frontiersin.org
Objective This study was designed to assess and analyze nutritional status (NS) and
immune status in patients with tuberculosis. Methods A retrospective analysis was …

Mycobacterium tuberculosis: Bacterial Fitness within the Host Macrophage

L Huang, EV Nazarova, DG Russell - Microbiology spectrum, 2019 - journals.asm.org
Mycobacterium tuberculosis has evolved to become the single greatest cause of death from
an infectious agent. The pathogen spends most of its infection cycle in its human host within …

[HTML][HTML] Accuracy of monocyte to lymphocyte ratio for tuberculosis diagnosis and its role in monitoring anti-tuberculosis treatment: Systematic review and meta …

T Adane, M Melku, G Ayalew, G Bewket, M Aynalem… - Medicine, 2022 - journals.lww.com
Background: High monocyte to lymphocyte ratio (MLR) values may be associated with the
risk of active tuberculosis (TB) infection in adults, infants, and postpartum women with HIV …

Can we predict tuberculosis cure? What tools are available?

D Goletti, CSL Arlehamn, TJ Scriba… - European …, 2018 - publications.ersnet.org
Antibiotic treatment of tuberculosis takes≥ 6 months, putting a major burden on patients and
health systems in large parts of the world. Treatment beyond 2 months is needed to prevent …

Monocyte, lymphocyte and neutrophil ratios–easy-to-use biomarkers for the diagnosis of pediatric tuberculosis

M Kissling, N Fritschi, P Baumann… - The Pediatric …, 2023 - journals.lww.com
Background: The neutrophil-to-lymphocyte-ratio (NLR), neutrophil-to-monocyte-plus-
lymphocyte-ratio (NMLR) and monocyte-to-lymphocyte-ratio (MLR) may have diagnostic …

[HTML][HTML] Diagnostic value of the neutrophil lymphocyte ratio in discrimination between tuberculosis and bacterial community acquired pneumonia: A meta-analysis

H Shojaan, N Kalami, MG Alamdari, SME Alorizy… - Journal of clinical …, 2023 - Elsevier
Background We conducted a systematic review and meta-analysis, based on Preferred
Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, to …