Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

This perspective focuses on advances in genome technology over the last 25 years and
their impact on germline variant discovery within the field of human genetics. The field has …

Simulation is a key tool in population genetics for both methods development and empirical
research, but producing simulations that recapitulate the main features of genomic datasets …

We sequenced and assembled using multiple long-read sequencing technologies the
genomes of chimpanzee, bonobo, gorilla, orangutan, gibbon, macaque, owl monkey, and …

Modern sequencing technology enables the systematic detection of complex structural
variation (SV) across genomes. However, extensive DNA rearrangements arising through a …

The protection of the replication fork structure under stress conditions is essential for
genome maintenance and cancer prevention. A key signaling pathway for fork protection …

Hematogenous metastasis is the main approach for colorectal cancer liver metastasis
(CRCLM). However, as the gatekeepers in the tumor vessels, the role of TPCs in …

Structural variants (SVs)—including duplications, deletions, and inversions of DNA—can
have significant genomic and functional impacts but are technically difficult to identify and …

The expressed Ab repertoire is a critical determinant of immune-related phenotypes. Ab-
encoding transcripts are distinct from other expressed genes because they are transcribed …

Structural variations (SVs) play important roles in human evolution and diseases, but there is
a lack of data resources concerning representative samples, especially for East Asians …