The production of induced pluripotent stem cells (iPSCs) represent a breakthrough in
regenerative medicine, providing new opportunities for understanding basic molecular …

Delta-like non-canonical Notch ligand 1 (DLK1) is a cleavable single-pass transmembrane
protein and a member of the Notch/Delta/Serrate family. It is paternally expressed and …

Abstract The 14q32. 2 (DLK1‐DIO3) and 15q11‐q13 (SNURF‐SNRPN) imprinted gene loci
harbor the largest known small nucleolar RNA clusters expressed from the respective …

Background Early lung cancer detection remains a clinical challenge for standard diagnostic
biopsies due to insufficient tumor morphological evidence. As epigenetic alterations precede …

Background MicroRNAs (miRNAs) are frequently deregulated in various types of cancer.
While antisense oligonucleotides are used to block oncomiRs, delivery of tumour …

Aims: MicroRNAs are regulators of (patho) physiological functions with tissue-specific
expression patterns. However, little is known about inter-vascular differences in microRNA …

The placenta is a unique organ for ensuring normal embryonic growth in the uterine. Here,
we found that maternal RNA transcription in Dlk1-Dio3 imprinted domain is essential for …

Epigenetics is a process that involves the regulation of gene expression without altering the
sequence of DNA. Numerous studies have documented that epigenetic mechanisms play a …

Relapsing-remitting multiple sclerosis (RRMS) is the most prevalent course of multiple
sclerosis. It is an autoimmune inflammatory disease of the central nervous system. To …

Abstract The mammalian imprinted Dlk1-Dio3 domain contains multiple lncRNAs, mRNAs,
the largest miRNA cluster in the genome and four differentially methylated regions (DMRs) …