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Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer
Abstract Changes in chromatin structure mediated by ATP-dependent nucleosome
remodelers and histone modifying enzymes are integral to the process of gene regulation …
remodelers and histone modifying enzymes are integral to the process of gene regulation …
Cryo-EM structure of SWI/SNF complex bound to a nucleosome
The chromatin-remodelling complex SWI/SNF is highly conserved and has critical roles in
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …
Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers
S Schick, AF Rendeiro, K Runggatscher, A Ringler… - Nature …, 2019 - nature.com
Aberrations in genes coding for subunits of the BRG1/BRM associated factor (BAF)
chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not …
chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not …
[HTML][HTML] Natural and engineered cyclodipeptides: Biosynthesis, chemical diversity, and engineering strategies for diversification and high-yield bioproduction.
WS Widodo, S Billerbeck - Engineering Microbiology, 2023 - Elsevier
Cyclodipeptides are diverse chemical scaffolds that show a broad range of bioactivities
relevant for medicine, agriculture, chemical catalysis, and material sciences …
relevant for medicine, agriculture, chemical catalysis, and material sciences …
Somatic ARID1A mutation stratifies patients with gastric cancer to PD-1 blockade and adjuvant chemotherapy
Y Gu, P Zhang, J Wang, C Lin, H Liu, H Li, H He… - Cancer Immunology …, 2023 - Springer
Background AT-rich interaction domain 1A (ARID1A) encodes a vital component of
switch/sucrose non-fermentable chromatin-remodeling complex. Given its association with …
switch/sucrose non-fermentable chromatin-remodeling complex. Given its association with …
Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement
Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin
remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (R …
remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (R …
High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer
JA Guerrero-Martínez, JC Reyes - Scientific reports, 2018 - nature.com
The gene encoding the ATPase of the chromatin remodeling SWI/SNF complexes
SMARCA4 (BRG1) is often mutated or silenced in tumors, suggesting a role as tumor …
SMARCA4 (BRG1) is often mutated or silenced in tumors, suggesting a role as tumor …
Snf2 controls pulcherriminic acid biosynthesis and antifungal activity of the biocontrol yeast Metschnikowia pulcherrima
D Gore‐Lloyd, I Sumann, AO Brachmann… - Molecular …, 2019 - Wiley Online Library
Metschnikowia pulcherrima synthesises the pigment pulcherrimin, from cyclodileucine (cyclo
(Leu‐Leu)) as a precursor, and exhibits strong antifungal activity against notorious plant …
(Leu‐Leu)) as a precursor, and exhibits strong antifungal activity against notorious plant …
Metabolic network remodelling enhances yeast's fitness on xylose using aerobic glycolysis
The reprogramming of metabolism in response to switching the carbon source from glucose
to non-preferred carbon sources is well-studied for yeast. However, understanding how …
to non-preferred carbon sources is well-studied for yeast. However, understanding how …
[HTML][HTML] Recurrent SMARCB1 mutations reveal a nucleosome acidic patch interaction site that potentiates mSWI/SNF complex chromatin remodeling
Mammalian switch/sucrose non-fermentable (mSWI/SNF) complexes are multi-component
machines that remodel chromatin architecture. Dissection of the subunit-and domain …
machines that remodel chromatin architecture. Dissection of the subunit-and domain …