Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer

AP Bracken, GL Brien, CP Verrijzer - Genes & development, 2019 - genesdev.cshlp.org
Abstract Changes in chromatin structure mediated by ATP-dependent nucleosome
remodelers and histone modifying enzymes are integral to the process of gene regulation …

Cryo-EM structure of SWI/SNF complex bound to a nucleosome

Y Han, AA Reyes, S Malik, Y He - Nature, 2020 - nature.com
The chromatin-remodelling complex SWI/SNF is highly conserved and has critical roles in
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …

Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers

S Schick, AF Rendeiro, K Runggatscher, A Ringler… - Nature …, 2019 - nature.com
Aberrations in genes coding for subunits of the BRG1/BRM associated factor (BAF)
chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not …

[HTML][HTML] Natural and engineered cyclodipeptides: Biosynthesis, chemical diversity, and engineering strategies for diversification and high-yield bioproduction.

WS Widodo, S Billerbeck - Engineering Microbiology, 2023 - Elsevier
Cyclodipeptides are diverse chemical scaffolds that show a broad range of bioactivities
relevant for medicine, agriculture, chemical catalysis, and material sciences …

Somatic ARID1A mutation stratifies patients with gastric cancer to PD-1 blockade and adjuvant chemotherapy

Y Gu, P Zhang, J Wang, C Lin, H Liu, H Li, H He… - Cancer Immunology …, 2023 - Springer
Background AT-rich interaction domain 1A (ARID1A) encodes a vital component of
switch/sucrose non-fermentable chromatin-remodeling complex. Given its association with …

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement

AB Patel, CM Moore, BJ Greber, J Luo, SA Zukin… - Elife, 2019 - elifesciences.org
Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin
remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (R …

High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer

JA Guerrero-Martínez, JC Reyes - Scientific reports, 2018 - nature.com
The gene encoding the ATPase of the chromatin remodeling SWI/SNF complexes
SMARCA4 (BRG1) is often mutated or silenced in tumors, suggesting a role as tumor …

Snf2 controls pulcherriminic acid biosynthesis and antifungal activity of the biocontrol yeast Metschnikowia pulcherrima

D Gore‐Lloyd, I Sumann, AO Brachmann… - Molecular …, 2019 - Wiley Online Library
Metschnikowia pulcherrima synthesises the pigment pulcherrimin, from cyclodileucine (cyclo
(Leu‐Leu)) as a precursor, and exhibits strong antifungal activity against notorious plant …

Metabolic network remodelling enhances yeast's fitness on xylose using aerobic glycolysis

X Li, Y Wang, G Li, Q Liu, R Pereira, Y Chen… - Nature Catalysis, 2021 - nature.com
The reprogramming of metabolism in response to switching the carbon source from glucose
to non-preferred carbon sources is well-studied for yeast. However, understanding how …

[HTML][HTML] Recurrent SMARCB1 mutations reveal a nucleosome acidic patch interaction site that potentiates mSWI/SNF complex chromatin remodeling

AM Valencia, CK Collings, HT Dao, RS Pierre… - Cell, 2019 - cell.com
Mammalian switch/sucrose non-fermentable (mSWI/SNF) complexes are multi-component
machines that remodel chromatin architecture. Dissection of the subunit-and domain …