Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research
X Tong, R Tang, M **ao, J Xu, W Wang… - Journal of hematology & …, 2022 - Springer
Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …
body against pathogenic substances. This process, called regulated cell death (RCD), is …
Cuproptosis and Cuproptosis‐Based Synergistic Therapy for Cancer Treatment
Z Shen, Y Qiu, H Ding, F Ren, H Chen - ChemMedChem, 2024 - Wiley Online Library
Copper, as an essential trace nutrient for human, plays a crucial role in numerous cellular
activities, and is vital for maintaining homeostasis in organisms. Deviations from normal …
activities, and is vital for maintaining homeostasis in organisms. Deviations from normal …
Cuproptosis-related MiR-21-5p/FDX1 axis in clear cell renal cell carcinoma and its potential impact on tumor microenvironment
M **e, B Cheng, S Yu, Y He, Y Cao, T Zhou, K Han… - Cells, 2022 - mdpi.com
As a newly identified type of programmed cell death, cuproptosis may have an impact on
cancer development, including clear cell renal cell carcinoma (ccRCC). Herein, we first …
cancer development, including clear cell renal cell carcinoma (ccRCC). Herein, we first …
Systematic analysis of integrated bioinformatics to identify upregulated THBS2 expression in colorectal cancer cells inhibiting tumour immunity through the HIF1A …
Y Liu, C Jiang, C Xu, L Gu - Cancer Cell International, 2023 - Springer
Background THBS2, a member of the extracellular matrix glycoprotein family, can effectively
inhibit tumour growth and angiogenesis. This study aimed to investigate the biological role …
inhibit tumour growth and angiogenesis. This study aimed to investigate the biological role …
Development and validation of cuproptosis-related lncRNAs associated with pancreatic cancer immune microenvironment based on single-cell
Y Sun, L Yao, C Man, Z Gao, R He, Y Fan - Frontiers in Immunology, 2023 - frontiersin.org
Background Cuproptosis, a novel mode of cell death associated with the tricarboxylic acid
(TCA) cycle, is relevant to the development of cancer. However, the impact of single-cell …
(TCA) cycle, is relevant to the development of cancer. However, the impact of single-cell …
Evaluation the role of cuproptosis-related genes in the pathogenesis, diagnosis and molecular subtypes identification of atherosclerosis
M Wang, L Cheng, Q **ang, Z Gao, Y Ding, H **e… - Heliyon, 2023 - cell.com
Background At present, the pathogenesis of atherosclerosis has not been fully elucidated,
and the diagnosis and treatment face great challenges. Cuproptosis is a novel cell death …
and the diagnosis and treatment face great challenges. Cuproptosis is a novel cell death …
Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC
Y Wang, X Zhang, G Chen, Q **ng, B Zhu, X Wang - Genes & Immunity, 2023 - nature.com
Abstract The ferredoxin 1 (FDX1) gene had been recently reported as a critical mediator of
cuproptosis, and without doubt, its roles in KIRC would be of importance. Hence, this paper …
cuproptosis, and without doubt, its roles in KIRC would be of importance. Hence, this paper …
[HTML][HTML] The potential of targeting cuproptosis in the treatment of kidney renal clear cell carcinoma
G Lei, L Tang, Y Yu, W Bian, L Yu, J Zhou, Y Li… - Biomedicine & …, 2023 - Elsevier
Renal cell carcinoma (RCC) is one of the top ten malignancies and tumor-related causes of
death worldwide. The most common histologic subtype is kidney renal clear cell carcinoma …
death worldwide. The most common histologic subtype is kidney renal clear cell carcinoma …
Cuproptosis-related gene CDKN2A as a molecular target for IPF diagnosis and therapeutics
B Xu, K Yang, X Han, J Hou - Inflammation Research, 2023 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a progressive chronic interstitial lung
disease with limited therapeutic options. Cuproptosis is a recently proposed novel form of …
disease with limited therapeutic options. Cuproptosis is a recently proposed novel form of …
The therapeutic and prognostic role of cuproptosis-related genes in triple negative breast cancer
B Shi, W Zhang, T Wang, Z Cui - BMC bioinformatics, 2023 - Springer
Background This study aimed to observe the potential impact of known cuproptosis-related
genes (CRGs) on triple negative breast cancer (TNBC) development, as well as their …
genes (CRGs) on triple negative breast cancer (TNBC) development, as well as their …