Adhesion can be quantified by measuring the distance between the interacting surfaces.
Reflection interference contrast microscopy (RICM), with its ability to measure inter‐surface …

The mechanisms of red blood cell (RBC) deformation under both static and dynamic, ie,
flow, conditions have been studied extensively since the mid 1960s. Deformation-induced …

Adhesion in humid conditions is a fundamental challenge to both natural and synthetic
adhesives. Yet, glue from most spider species becomes stickier as humidity increases. We …

Precise manipulation of single molecules has already led to remarkable insights in physics,
chemistry, biology, and medicine. However, widespread adoption of single-molecule …

The ability to apply controlled forces to individual molecules or molecular complexes and
observe their behaviors has led to many important discoveries in biology. Instruments …

Membrane receptor-ligand interactions mediate many cellular functions. Binding kinetics
and downstream signaling triggered by these molecular interactions are likely affected by …

A complete understanding of the cellular pathways involved in viral infections will ultimately
require a diverse arsenal of experimental techniques, including methods for tracking …

Interferometric techniques have proven useful to infer proximity and local surface profiles of
microscopic objects near surfaces. But a critical trade-off emerges between accuracy and …

We present an improved analysis of reflection interference contrast microscopy (RICM)
images, recorded to investigate model membrane systems that mimic cell adhesion. The …

Abstract Traction Force Microscopy (TFM) computes the forces exerted at the surface of an
elastic material by measuring induced deformations in volume. It is used to determine the …