Muscle wasting in disease: molecular mechanisms and promising therapies
S Cohen, JA Nathan, AL Goldberg - Nature reviews Drug discovery, 2015 - nature.com
Atrophy occurs in specific muscles with inactivity (for example, during plaster cast
immobilization) or denervation (for example, in patients with spinal cord injuries). Muscle …
immobilization) or denervation (for example, in patients with spinal cord injuries). Muscle …
Metabolic reprograming in macrophage polarization
Studying the metabolism of immune cells in recent years has emphasized the tight link
existing between the metabolic state and the phenotype of these cells. Macrophages in …
existing between the metabolic state and the phenotype of these cells. Macrophages in …
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
KS Vimaleswaran, DJ Berry, C Lu, E Tikkanen… - PLoS …, 2013 - journals.plos.org
Background Obesity is associated with vitamin D deficiency, and both are areas of active
public health concern. We explored the causality and direction of the relationship between …
public health concern. We explored the causality and direction of the relationship between …
[HTML][HTML] Endothelial cell senescence in aging-related vascular dysfunction
G Jia, AR Aroor, C Jia, JR Sowers - … Acta (BBA)-Molecular Basis of Disease, 2019 - Elsevier
Increased cardiovascular disease in aging is partly a consequence of the vascular
endothelial cell (EC) senescence and associated vascular dysfunction. In this contest, EC …
endothelial cell (EC) senescence and associated vascular dysfunction. In this contest, EC …
Mitochondrial biogenesis and clearance: a balancing act
Mitochondria are semi‐autonomous organelles of prokaryotic origin that are postulated to
have been acquired by eukaryotic cells through an early endosymbiotic event. Except for …
have been acquired by eukaryotic cells through an early endosymbiotic event. Except for …
HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC‐to‐EpiSC/hESC transition
W Zhou, M Choi, D Margineantu, L Margaretha… - The EMBO …, 2012 - embopress.org
The function of metabolic state in stemness is poorly understood. Mouse embryonicstem
cells (ESC) and epiblast stem cells (EpiSC) are at distinct pluripotent statesrepresenting the …
cells (ESC) and epiblast stem cells (EpiSC) are at distinct pluripotent statesrepresenting the …
New insights into PGC‐1 coactivators: redefining their role in the regulation of mitochondrial function and beyond
JA Villena - The FEBS journal, 2015 - Wiley Online Library
Members of the PGC‐1 family of coactivators have been revealed as key players in the
regulation of energy metabolism. Early gain‐and loss‐of‐function studies led to the …
regulation of energy metabolism. Early gain‐and loss‐of‐function studies led to the …
Metabolic reprogramming of macrophages during infections and cancer
S Wang, R Liu, Q Yu, L Dong, Y Bi, G Liu - Cancer letters, 2019 - Elsevier
In response to different microenvironmental stimuli, macrophages are polarized into two
populations, M1 macrophages which are classically activated by interferon (IFN)-γ with …
populations, M1 macrophages which are classically activated by interferon (IFN)-γ with …
Mitochondrial DNA transcription and its regulation: an evolutionary perspective
The bacterial heritage of mitochondria, as well as its independent genome [mitochondrial
DNA (mtDNA)] and polycistronic transcripts, led to the view that mitochondrial transcriptional …
DNA (mtDNA)] and polycistronic transcripts, led to the view that mitochondrial transcriptional …
Flavonoids and mitochondria: activation of cytoprotective pathways?
A Kicinska, W Jarmuszkiewicz - Molecules, 2020 - mdpi.com
A large number of diverse mechanisms that lead to cytoprotection have been described to
date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In …
date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In …