The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

T Cernak, KD Dykstra, S Tyagarajan… - Chemical Society …, 2016 - pubs.rsc.org
The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …

Modern advances in heterocyclic chemistry in drug discovery

AP Taylor, RP Robinson, YM Fobian… - Organic & …, 2016 - pubs.rsc.org
New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …

Liquid phase oxidation chemistry in continuous-flow microreactors

HPL Gemoets, Y Su, M Shang, V Hessel… - Chemical Society …, 2016 - pubs.rsc.org
Continuous-flow liquid phase oxidation chemistry in microreactors receives a lot of attention
as the reactor provides enhanced heat and mass transfer characteristics, safe use of …

The evolution of chemical high-throughput experimentation to address challenging problems in pharmaceutical synthesis

SW Krska, DA DiRocco, SD Dreher… - Accounts of chemical …, 2017 - ACS Publications
Conspectus The structural complexity of pharmaceuticals presents a significant challenge to
modern catalysis. Many published methods that work well on simple substrates often fail …

Enabling technologies for the future of chemical synthesis

DE Fitzpatrick, C Battilocchio, SV Ley - ACS central science, 2016 - ACS Publications
Technology is evolving at breakneck pace, changing the way we communicate, travel, find
out information, and live our lives. Yet chemistry as a science has been slower to adapt to …

Toward the institutionalization of quantum computing in pharmaceutical research

M Zinner, F Dahlhausen, P Boehme, J Ehlers… - Drug Discovery …, 2022 - Elsevier
Innovative pharmaceutical companies have started to explore quantum computing (QC). In
this article, we provide a collective industry perspective from QC domain leaders at leading …

Engineering chemistry for the future of chemical synthesis

DE Fitzpatrick, SV Ley - Tetrahedron, 2018 - Elsevier
Synthesis is changing in response to our modern resource conscious world. The principles
of green chemistry are evolving as the interfaces and boundaries in science are less …

[HTML][HTML] A new digital value chain model with PLC in biopharmaceutical industry: the implication for open innovation

YC Kim, E Atukeren, YW Lee - … of Open Innovation: Technology, Market, and …, 2022 - Elsevier
The advancement of technology in the biopharmaceutical industry has spearheaded the
speed and scale of digitalization in various aspects. New drug development is becoming …

Recent advances in high-throughput automated powder dispensing platforms for pharmaceutical applications

MN Bahr, MA Morris, NP Tu… - … Process Research & …, 2020 - ACS Publications
A wide array of pharmaceutical research studies involve dispensing a variety of powders
such as active ingredients, intermediates, catalysts, and formulation excipients. Automated …

The emergence of universal chromatographic methods in the research and development of new drug substances

EL Regalado, IA Haidar Ahmad, R Bennett… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Manufacturing process development of new drug substances in the
pharmaceutical industry combines numerous chemical challenges beyond the efficient …