The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
T Cernak, KD Dykstra, S Tyagarajan… - Chemical Society …, 2016 - pubs.rsc.org
The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …
Modern advances in heterocyclic chemistry in drug discovery
AP Taylor, RP Robinson, YM Fobian… - Organic & …, 2016 - pubs.rsc.org
New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …
Liquid phase oxidation chemistry in continuous-flow microreactors
Continuous-flow liquid phase oxidation chemistry in microreactors receives a lot of attention
as the reactor provides enhanced heat and mass transfer characteristics, safe use of …
as the reactor provides enhanced heat and mass transfer characteristics, safe use of …
The evolution of chemical high-throughput experimentation to address challenging problems in pharmaceutical synthesis
Conspectus The structural complexity of pharmaceuticals presents a significant challenge to
modern catalysis. Many published methods that work well on simple substrates often fail …
modern catalysis. Many published methods that work well on simple substrates often fail …
Enabling technologies for the future of chemical synthesis
DE Fitzpatrick, C Battilocchio, SV Ley - ACS central science, 2016 - ACS Publications
Technology is evolving at breakneck pace, changing the way we communicate, travel, find
out information, and live our lives. Yet chemistry as a science has been slower to adapt to …
out information, and live our lives. Yet chemistry as a science has been slower to adapt to …
Toward the institutionalization of quantum computing in pharmaceutical research
Innovative pharmaceutical companies have started to explore quantum computing (QC). In
this article, we provide a collective industry perspective from QC domain leaders at leading …
this article, we provide a collective industry perspective from QC domain leaders at leading …
Engineering chemistry for the future of chemical synthesis
DE Fitzpatrick, SV Ley - Tetrahedron, 2018 - Elsevier
Synthesis is changing in response to our modern resource conscious world. The principles
of green chemistry are evolving as the interfaces and boundaries in science are less …
of green chemistry are evolving as the interfaces and boundaries in science are less …
[HTML][HTML] A new digital value chain model with PLC in biopharmaceutical industry: the implication for open innovation
The advancement of technology in the biopharmaceutical industry has spearheaded the
speed and scale of digitalization in various aspects. New drug development is becoming …
speed and scale of digitalization in various aspects. New drug development is becoming …
Recent advances in high-throughput automated powder dispensing platforms for pharmaceutical applications
MN Bahr, MA Morris, NP Tu… - … Process Research & …, 2020 - ACS Publications
A wide array of pharmaceutical research studies involve dispensing a variety of powders
such as active ingredients, intermediates, catalysts, and formulation excipients. Automated …
such as active ingredients, intermediates, catalysts, and formulation excipients. Automated …
The emergence of universal chromatographic methods in the research and development of new drug substances
Conspectus Manufacturing process development of new drug substances in the
pharmaceutical industry combines numerous chemical challenges beyond the efficient …
pharmaceutical industry combines numerous chemical challenges beyond the efficient …