Chromatin remodellers were once thought to be highly redundant and nonspecific in their
actions. However, recent human genetic studies demonstrate remarkable biological …

Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the
eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot …

Herpes simplex virus (HSV) establishes a latent infection in peripheral neurons and can
periodically reactivate to cause disease. Reactivation can be triggered by a variety of stimuli …

Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with
impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other …

The current World Health Organization classification of CNS tumors has made a tremendous
leap from past editions by incorporating molecular criteria in addition to the pre-existing …

A considerable fraction of the eukaryotic genome is made up of satellite DNA constituted of
tandemly repeated sequences. These elements are mainly located at centromeres …

Mutations in CDCA7, the SNF2 family protein HELLS (LSH), or the DNA methyltransferase
DNMT3b cause immunodeficiency–centromeric instability–facial anomalies (ICF) syndrome …

Herpes simplex virus (HSV-1) lytic infection results in global changes to the host cell
proteome and the proteins associated with host chromatin. We present a system level …

H3. 3 is a highly conserved nonreplicative histone variant. H3. 3 is enriched in promoters
and enhancers of active genes, but it is also found within suppressed heterochromatin …

Expansive growth of neural progenitor cells (NPCs) is a prerequisite to the temporal waves
of neuronal differentiation that generate the six-layered neocortex, while also placing a …