Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

Over the last 3 decades, monoclonal antibodies have become the most important class of
therapeutic biologicals on the market. Development of therapeutic antibodies was …

Importance Current treatments for long-term prophylaxis in hereditary angioedema have
limitations. Objective To assess the efficacy of lanadelumab, a fully human monoclonal …

Rapid upregulation of matrix metalloproteinase 9 (MMP-9) leads to blood-brain barrier
(BBB) breakdown following stroke, but no MMP-9 inhibitors have been approved in clinic …

Background Hereditary angioedema with C1 inhibitor deficiency is characterized by
recurrent, unpredictable swelling episodes caused by uncontrolled plasma kallikrein …

The phage display technology is based on the presentation of peptide sequences on the
surface of virions of bacteriophages. Its development led to creation of sophisticated systems …

Background The aim was to evaluate long‐term effectiveness and safety of lanadelumab in
patients≥ 12 y old with hereditary angioedema (HAE) 1/2 (NCT02741596). Methods …

The epidermis is a barrier that prevents water loss while kee** harmful substances from
penetrating the host. The impermeable cornified layer of the stratum corneum is maintained …

Introduction: Over the past decade, several library-based methods have been developed to
discover ligands with strong binding affinities for their targets. These methods mimic the …

Bradykinin, a member of the kallikrein–kinin system (KKS), is a potent, short-lived vasoactive
peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling …