Cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are increasingly used to
model cardiac disease, test drug efficacy and for safety pharmacology. Nevertheless, a …

Connexins, the protein molecules forming gap junction channels, are reduced in number or
redistributed from intercalated disks to lateral cell borders in a variety of cardiac diseases …

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …

The experimental and clinical possibilities for studying cardiac arrhythmias in human
ventricular myocardium are very limited. Therefore, the use of alternative methods such as …

Ventricular fibrillation (VF) is one of the main causes of death in the Western world.
According to one hypothesis, the chaotic excitation dynamics during VF are the result of …

Background: Human engineered heart tissue (EHT) transplantation represents a potential
regenerative strategy for patients with heart failure and has been successful in preclinical …

Human-based modelling and simulations are becoming ubiquitous in biomedical science
due to their ability to augment experimental and clinical investigations. Cardiac …

Modeling the dynamics of wave propagation in human ventricular tissue and studying wave
stability require models that reproduce realistic characteristics in tissue. We present a …

Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …