Overcoming roadblocks in the development of vaccines for leishmaniasis
PM Kaye, S Mohan, C Mantel, M Malhame… - Expert Review of …, 2021 - Taylor & Francis
Introduction The leishmaniases represent a group of parasitic diseases caused by infection
with one of several species of Leishmania parasites. Disease presentation varies because …
with one of several species of Leishmania parasites. Disease presentation varies because …
Leishmaniasis: Omics approaches to understand its biology from molecule to cell level
Leishmaniasis is the second deadliest vector-borne, neglected tropical zoonotic disease
and is found in a variety of clinical forms based on genetic background. Its endemic type is …
and is found in a variety of clinical forms based on genetic background. Its endemic type is …
Parasite genotype is a major predictor of mortality from visceral leishmaniasis
CA Grace, KS Sousa Carvalho, MI Sousa Lima… - MBio, 2022 - Am Soc Microbiol
Visceral leishmaniasis (VL) is a potentially fatal disease caused mainly by Leishmania
infantum in South America and Leishmania donovani in Asia and Africa. Disease outcomes …
infantum in South America and Leishmania donovani in Asia and Africa. Disease outcomes …
Identification of Leishmania infantum Epidemiology, Drug Resistance and Pathogenicity Biomarkers with Nanopore Sequencing
J Martí-Carreras, M Carrasco, M Gómez-Ponce… - Microorganisms, 2022 - mdpi.com
The emergence of drug-resistant strains of the parasite Leishmania infantum infecting dogs
and humans represents an increasing threat. L. infantum genomes are complex and …
and humans represents an increasing threat. L. infantum genomes are complex and …
[HTML][HTML] Geographic origin and vertical transmission of Leishmania infantum parasites in hunting hounds, United States
Vertical transmission of leishmaniasis is common but is difficult to study against the
background of pervasive vector transmission. We present genomic data from dogs in the …
background of pervasive vector transmission. We present genomic data from dogs in the …
Diversity and within-host evolution of Leishmania donovani from visceral leishmaniasis patients with and without HIV coinfection in northern Ethiopia
SU Franssen, Y Takele, E Adem, MJ Sanders, I Müller… - MBio, 2021 - Am Soc Microbiol
Visceral leishmaniasis (VL) is a fatal disease and a growing public health problem in East
Africa, where Ethiopia has one of the highest VL burdens. The largest focus of VL in Ethiopia …
Africa, where Ethiopia has one of the highest VL burdens. The largest focus of VL in Ethiopia …
Synthetic Peptides Selected by Immunoinformatics as Potential Tools for the Specific Diagnosis of Canine Visceral Leishmaniasis
G Moreira, R Maia, N Soares, T Ostolin, W Coura-Vital… - Microorganisms, 2024 - mdpi.com
Diagnosing canine visceral leishmaniasis (CVL) in Brazil faces challenges due to the
limitations regarding the sensitivity and specificity of the current diagnostic protocol …
limitations regarding the sensitivity and specificity of the current diagnostic protocol …
Miltefosine Unresponsiveness in Visceral Leishmaniasis
Abstract Treatment failure in visceral leishmaniasis (VL; kala-azar) is an increasing problem
worldwide, primarily due to drug resistance. Pentavalent antimonials were the mainstay of …
worldwide, primarily due to drug resistance. Pentavalent antimonials were the mainstay of …
Evaluation by molecular docking of inhibitors of the enzyme pteridine reductase 1 from leishmania
Objective: The objective of this work is to perform a bioactive analysis of Leishmania major
Pteridine Reductase 1 inhibitors (LmPTR1) through in silico molecular docking studies …
Pteridine Reductase 1 inhibitors (LmPTR1) through in silico molecular docking studies …
Multiple targets of balancing selection in Leishmania donovani complex parasites
The Leishmania donovani species complex are the causative agents of visceral
leishmaniasis, which cause 20-40,000 fatalities a year. Here, we conduct a screen for …
leishmaniasis, which cause 20-40,000 fatalities a year. Here, we conduct a screen for …