A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …

All lifeforms have developed highly sophisticated systems equipped to detect altered self
and non-self nucleic acids (NA). In vertebrates, NA-sensing receptors safeguard the integrity …

A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

The Flavivirus genus consists of> 70 members including several that are considered
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …

Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of
antiviral therapies. Understanding host proteins essential for IAV infection can identify …

The eukaryotic mRNA surveillance pathway, a pivotal guardian of mRNA fidelity, stands at
the nexus of diverse biological processes, including antiviral immunity. Despite the …

The term 'nonsense-mediated mRNA decay'(NMD) was initially coined to describe the
translation-dependent degradation of mRNAs harboring premature termination codons …

DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to
the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family …

RNA quality control nonsense-mediated decay is involved in viral restriction in both plants
and animals. However, it is not known whether two other RNA quality control pathways …

Flaviviruses comprise a genus of viruses that pose a significant burden on human health
worldwide. Transmission by both mosquito and tick vectors, and broad host tropism …