Reassessing Human Adipose Tissue Adipose tissue can more than double in mass and
then return to baseline. This review discusses the functional roles of human white and brown …

The term “cachexia” is derived from the Greek words kakos (bad) and hexis (habit).
Cachexia is a malnutrition associated with chronic diseases such as cancer, chronic heart …

Adipose tissue is usually classified on the basis of its function as white, brown or beige
(brite). It is an important regulator of systemic metabolism, as shown by the fact that …

The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Brown adipose tissue (BAT) dissipates energy, and promotes cardiometabolic health. Loss
of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but …

Obesity induces chronic inflammation resulting in insulin resistance and metabolic
disorders. Cold exposure can improve insulin sensitivity in humans and rodents, but the …

We are host to an assembly of microorganisms that vary in structure and function along the
length of the gut and from the lumen to the mucosa. This ecosystem is collectively known as …

Adaptive thermogenesis by brown adipose tissue (BAT) dissipates calories as heat, making
it an attractive anti-obesity target. Yet how BAT contributes to circulating metabolite …

Overweight and obesity have become a world-wide problem. However, effective intervention
approaches are limited. Brown adipose tissue, which helps maintain body temperature and …