Viruses often deviate from their hosts in the nucleotide composition of their genomes. The
RNA genome of the lentivirus family of retroviruses, including human immunodeficiency …

Extracellular vesicles (EVs), of diverse origin and content, are membranous structures
secreted by a broad range of cell types. Recent advances in molecular biology have …

Human immunodeficiency virus type 1 Vpr is an accessory protein that induces G 2/M cell
cycle arrest. It is well documented that interaction of Vpr with the Cul4-DDB1 [VprBP] E3 …

APOBEC (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like) is a family of
enzymes that deaminates cytosine (C) to uracil (U) on nucleic acid. APOBEC3B (A3B) …

The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family proteins bind
RNA and single-stranded DNA, and create C-to-U base modifications through cytidine …

Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's
sarcoma (KS) and primary effusion lymphoma (PEL), which are aggressive malignancies …

Highlights•All RNA methyltransferases share a common structural core and use S-adenosyl
methionine as a methyl donor.•All RNA deaminases exhibit a common structural core and …

Human APOBEC3F (huA3F) potently restricts the infectivity of HIV-1 in the absence of the
viral accessory protein virion infectivity factor (Vif). Vif functions to preserve viral infectivity by …

We previously demonstrated the ability of HIV-1 Vpr protein to activate the oxidative stress
pathway, thus leading to the induction of the hypoxia inducible factor 1 alpha (HIF-1α) …

We document the anti-HIV activity of nitazoxanide (NTZ), the first member of the thiazolide
class of antiinfective drugs, originally effective against enteritis caused by Cryptosporidium …