Exploring the multifunctionality of SR proteins

I Slišković, H Eich… - Biochemical Society …, 2022 - portlandpress.com
Members of the arginine–serine-rich protein family (SR proteins) are multifunctional RNA-
binding proteins that have emerged as key determinants for mRNP formation, identity and …

Long non-coding RNAs in cardiac hypertrophy and heart failure: Functions, mechanisms and clinical prospects

JD Mably, DZ Wang - Nature Reviews Cardiology, 2024 - nature.com
The surge in reports describing non-coding RNAs (ncRNAs) has focused attention on their
possible biological roles and effects on development and disease. ncRNAs have been …

Higher order dynamic mode decomposition: From fluid dynamics to heart disease analysis

N Groun, M Villalba-Orero, E Lara-Pezzi… - Computers in Biology …, 2022 - Elsevier
In this work, we study in detail the performance of Higher Order Dynamic Mode
Decomposition (HODMD) technique when applied to echocardiography images. HODMD is …

Cardiac splicing as a diagnostic and therapeutic target

M Gotthardt, V Badillo-Lisakowski, VN Parikh… - Nature Reviews …, 2023 - nature.com
Despite advances in therapeutics for heart failure and arrhythmias, a substantial proportion
of patients with cardiomyopathy do not respond to interventions, indicating a need to identify …

Long noncoding RNAs in ubiquitination, protein degradation, and human diseases

P Guha, A Chini, A Rishi, SS Mandal - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
Protein stability and turnover is critical in normal cellular and physiological process and their
misregulation may contribute to accumulation of unwanted proteins causing cellular …

[HTML][HTML] Splicing factors in the heart: Uncovering shared and unique targets

P Montañés-Agudo, YM Pinto, EE Creemers - Journal of molecular and …, 2023 - Elsevier
Alternative splicing generates specialized protein isoforms that allow the heart to adapt
during development and disease. The recent discovery that mutations in the splicing factor …

Exosomal hsa-mir-335-5p and hsa-mir-483-5p are novel biomarkers for rheumatoid arthritis: a development and validation study

Y Yu, S Park, H Lee, EJ Kwon, HR Park, YH Kim… - International …, 2023 - Elsevier
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes
cartilage and bone damage. Exosomes are small extracellular vesicles that play a critical …

Retard or exacerbate: role of long non-coding RNA growth arrest-specific 5 in the fibrosis

Z **ang, Y Liqing, Y Qingqing, H Qiang… - Cytokine & Growth Factor …, 2022 - Elsevier
Fibrosis is the endpoint of pathological remodeling involving different expressions of non-
coding RNA (ncRNA) including long non-coding RNA growth arrest-specific 5 (lncRNA …

Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins

ER Hinkle, RE Blue, YH Tsai, M Combs, J Davi… - Communications …, 2022 - nature.com
Alternative splicing is an RNA processing mechanism involved in skeletal muscle
development and pathology. Muscular diseases exhibit splicing alterations and changes in …

p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1

AM Santamans, V Montalvo-Romeral, A Mora… - PLoS …, 2021 - journals.plos.org
During the first weeks of postnatal heart development, cardiomyocytes undergo a major
adaptive metabolic shift from glycolytic energy production to fatty acid oxidation. This …