The value of blood lactate kinetics in critically ill patients: a systematic review

JL Vincent, A Quintairos e Silva, L Couto, FS Taccone - Critical care, 2016 - Springer
Background The time course of blood lactate levels could be helpful to assess a patient's
response to therapy. Although the focus of published studies has been largely on septic …

Etiology and therapeutic approach to elevated lactate levels

LW Andersen, J Mackenhauer, JC Roberts… - Mayo Clinic …, 2013 - Elsevier
Lactate levels are commonly evaluated in acutely ill patients. Although most often used in
the context of evaluating shock, lactate levels can be elevated for many reasons. While …

Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database

B Casserly, GS Phillips, C Schorr… - Critical care …, 2015 - journals.lww.com
Objective: The Surviving Sepsis Campaign guidelines recommend obtaining a serum lactate
measurement within 6 hours of presentation for all patients with suspected severe sepsis or …

[HTML][HTML] Metformin is associated with higher incidence of acidosis, but not mortality, in individuals with COVID-19 and pre-existing type 2 diabetes

X Cheng, YM Liu, H Li, X Zhang, F Lei, JJ Qin, Z Chen… - Cell metabolism, 2020 - cell.com
The safety and efficacy of anti-diabetic drugs are critical for maximizing the beneficial
impacts of well-controlled blood glucose on the prognosis of individuals with COVID-19 and …

[PDF][PDF] The importance of monitoring blood lactate levels in critically ill patients: A focus on hyperlactatemia and resuscitation protocols.[ResearchGate]

I Karunarathna, A Jayawardana, S Bandara - 2024 - researchgate.net
Increased blood lactate levels, known as hyperlactatemia, are frequently observed in
critically ill patients. While elevated lactate is often used to diagnose inadequate tissue …

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

L Yang, M **e, M Yang, Y Yu, S Zhu, W Hou… - Nature …, 2014 - nature.com
Increasing evidence suggests the important role of metabolic reprogramming in the
regulation of the innate inflammatory response, but the underlying mechanism remains …

Severe hyperlactatemia, lactate clearance and mortality in unselected critically ill patients

SA Haas, T Lange, B Saugel, M Petzoldt… - Intensive care …, 2016 - Springer
Purpose Hyperlactatemia may occur for a variety of reasons and is a predictor of poor
clinical outcome. However, only limited data are available on the underlying causes of …

Early lactate clearance is associated with improved outcome in severe sepsis and septic shock

HB Nguyen, EP Rivers, BP Knoblich… - Critical care …, 2004 - journals.lww.com
Objective: Serial lactate concentrations can be used to examine disease severity in the
intensive care unit. This study examines the clinical utility of the lactate clearance before …

Clinical use of lactate monitoring in critically ill patients

J Bakker, MWN Nijsten, TC Jansen - Annals of intensive care, 2013 - Springer
Increased blood lactate levels (hyperlactataemia) are common in critically ill patients.
Although frequently used to diagnose inadequate tissue oxygenation, other processes not …

Serum lactate as a predictor of mortality in emergency department patients with infection

NI Shapiro, MD Howell, D Talmor, LA Nathanson… - Annals of emergency …, 2005 - Elsevier
STUDY OBJECTIVE: Little is known about risk-stratification biomarkers in emergency
department (ED) patients with suspected infection, and lactate is a biologically plausible …