Highlights•One-carbon compounds can be made from CO 2 to provide renewable microbial
feedstocks.•Methanol and formate have key advantages over gaseous one-carbon …

Genome-scale stoichiometric modeling of metabolism has become a standard systems
biology tool for modeling cellular physiology and growth. Extensions of this approach are …

Methanol synthesized from captured greenhouse gases is an emerging renewable
feedstock with great potential for bioproduction. Recent research has raised the prospect of …

The living world is largely divided into autotrophs that convert CO 2 into biomass and
heterotrophs that consume organic compounds. In spite of widespread interest in renewable …

Methanol is a liquid with high energy storage capacity that holds promise as an alternative
substrate to replace sugars in the biotechnology industry. It can be produced from CO2 or …

The initial genome‐scale reconstruction of the metabolic network of Escherichia coli K‐12
MG1655 was assembled in 2000. It has been updated and periodically released since then …

To drive innovation in chemical and material applications beyond what has been afforded by
the mature petrochemical industry, new molecules that possess diverse chemical …

Systemic approaches to the study of a biological cell or tissue rely increasingly on the use of
context-specific metabolic network models. The reconstruction of such a model from high …

Metabolic engineering aims to produce chemicals of interest from living organisms, to
advance toward greener chemistry. Despite efforts, the research and development process …

Many photosynthetic organisms employ a CO2 concentrating mechanism (CCM) to increase
the rate of CO2 fixation via the Calvin cycle. CCMs catalyze≈ 50% of global photosynthesis …