Glutamate as a neurotransmitter in the healthy brain

Y Zhou, NC Danbolt - Journal of neural transmission, 2014 - Springer
Glutamate is the most abundant free amino acid in the brain and is at the crossroad between
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …

GABA and glutamate transporters in brain

Y Zhou, NC Danbolt - Frontiers in endocrinology, 2013 - frontiersin.org
The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1;
GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes …

Decreased expression of GLT‐1 in the R6/2 model of Huntington's disease does not worsen disease progression

GT Petr, LA Schultheis, KC Hussey… - European Journal of …, 2013 - Wiley Online Library
Excitotoxicity is thought to be important in the pathogenesis of Huntington's disease (HD).
Glutamate is the predominant excitatory neurotransmitter in the brain, and excess activation …