Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

The striatum contributes to many cognitive processes and disorders, but its cell types are
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …

How species with similar repertoires of protein-coding genes differ so markedly at the
phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate …

Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …

Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by
infiltrating immune cells and by cytokines released by these cells. Signaling events …

In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …

Nuclear pore complexes (NPCs) are multiprotein aqueous channels that penetrate the
nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple …

Alternative splicing enhances transcriptome diversity in all eukaryotes and plays a role in
plant tissue identity and stress adaptation. To catalog new maize (Zea mays) transcripts and …