Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …

ABSTRACT SQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold
protein involved in diverse cellular processes. Its functions are tightly regulated through an …

The high incidence of aneuploidy in the embryo is considered the principal cause for low
human fecundity. However, the prevalence of aneuploidy dramatically declines as …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal
malignancies. Given that macroautophagy/autophagy activation is prevalent in PDAC, the …

Autophagy and the Keap1–Nrf2 system are major cellular defense mechanisms against
metabolic and oxidative stress. These two systems are linked via phosphorylation of the …

Biomineralization in vertebrates is initiated via amorphous calcium phosphate (ACP)
precursors. These precursors infiltrate the extracellular collagen matrix where they undergo …

Autophagy is an intracellular process that targets various cargos for degradation, including
members of the cGAS-STING signaling cascade. cGAS-STING senses cytosolic double …

Abstract p62 is associated with 2 major cellular defense mechanisms against metabolic and
oxidative stress, autophagy and the Kelch‐like ECH‐associated protein 1 (KEAP1)‐nuclear …

Autophagy is an essential function to breakdown cellular proteins and organelles to recycle
for new nutrient building blocks. In colorectal cancer, the importance of autophagy is …

Cancer cells reprogram cellular metabolism to maintain adequate nutrient pools to sustain
proliferation. Moreover, autophagy is a regulated mechanism to break down dysfunctional …